Reprint of "DNA, the central molecule of aging"
Status PubMed-not-MEDLINE Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články, přehledy
PubMed
27133220
DOI
10.1016/j.mrfmmm.2016.04.002
PII: S0027-5107(16)30047-1
Knihovny.cz E-zdroje
- Klíčová slova
- Aging, Chromatin structure, DNA, DNA damage, DNA repair, Mutagenesis, Telomeres,
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
Understanding the molecular mechanism of aging could have enormous medical implications. Despite a century of research, however, there is no universally accepted theory regarding the molecular basis of aging. On the other hand, there is plentiful evidence suggesting that DNA constitutes the central molecule in this process. Here, we review the roles of chromatin structure, DNA damage, and shortening of telomeres in aging and propose a hypothesis for how their interplay leads to aging phenotypes.
Citace poskytuje Crossref.org
