Low Plasma Cholinesterase Activities are Associated with Deficits in Spatial Orientation, Reduced Ability to Perform Basic Activities of Daily Living, and Low Body Mass Index in Patients with Progressed Alzheimer's Disease
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
26890780
DOI
10.3233/jad-151060
PII: JAD151060
Knihovny.cz E-resources
- Keywords
- Activities of daily living, Alzheimer’s disease, body mass index, cholinesterases, cognition, spatial orientation,
- MeSH
- Acetylcholinesterase blood MeSH
- Alzheimer Disease physiopathology therapy MeSH
- Blood Chemical Analysis MeSH
- Butyrylcholinesterase blood MeSH
- Activities of Daily Living * MeSH
- Hospitalization MeSH
- Body Mass Index * MeSH
- Middle Aged MeSH
- Humans MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Orientation, Spatial physiology MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Acetylcholinesterase MeSH
- Butyrylcholinesterase MeSH
Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disorder characterized by a central cholinergic deficit. Non-neuronal cholinergic changes are, however, described as well. Here we focused on possible changes in the activity of the plasma cholinesterases, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), in hospitalized AD patients. We analyzed plasma AChE and BChE activities with regards to age, gender, body mass index (BMI), cognitive functions, and ability to perform activities of daily living in AD patients in comparison to healthy subjects. We observed lower AChE activity and trend toward lower BChE activity in AD patients, which both correlated with low BMI. AD patients unable to perform basic activities of daily living (feeding, bathing, dressing, and grooming) showed reduced plasma AChE activities, while worse spatial orientation was linked to lower BChE activities. Three out of four AD patients with the lowest BChE activities died within one year. In conclusion, progressed AD was accompanied by lower plasma AChE activity and trend toward lower BChE activity, which correlated with BMI and deficits in different components of the AD.
References provided by Crossref.org
Aortic butyrylcholinesterase is reduced in spontaneously hypertensive rats
