Study on mutual interactions and electronic structures of hyaluronan with Lysine, 6-Aminocaproic acid and Arginine
Jazyk angličtina Země Velká Británie, Anglie Médium print-electronic
Typ dokumentu časopisecké články
PubMed
26917367
DOI
10.1016/j.carbpol.2016.01.035
PII: S0144-8617(16)00050-3
Knihovny.cz E-zdroje
- Klíčová slova
- Amino acids, Density functional theory (DFT), Hyaluronan, Interactions, Rheology,
- MeSH
- arginin chemie metabolismus MeSH
- kyselina 6-aminokapronová chemie metabolismus MeSH
- kyselina hyaluronová chemie metabolismus MeSH
- lysin chemie metabolismus MeSH
- molekulární modely MeSH
- vazebná místa MeSH
- viskozita MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- arginin MeSH
- kyselina 6-aminokapronová MeSH
- kyselina hyaluronová MeSH
- lysin MeSH
Interactions between polyelectrolytes and oppositely charged surfactants have been in a great interest for several decades, yet the conventional surfactants may cause a problem in medical applications. Interactivity between polysaccharide hyaluronan (HA) and amino acids Lysine, 6-Aminocaproic acid (6-AcA), and Arginine as an alternative system is reported. The interactions were investigated by means of rheology and electric conductance and the electronic structures were explored by the density functional theory (DFT). Lysine exhibits the strongest interaction of all, which was manifested, e.g. by nearly 6-time drop of the initial viscosity comparing with only 1.3-time lower value in the case of 6-AcA. Arginine interaction with HA was surprisingly weaker in terms of viscosity than that of Lysine due to a lower and delocalized charge density on its guanidine group. According to the DFT calculations, the binding of Lysine to HA was found to be more flexible, while Arginine creates more rigid structure with HA.
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