Drugs related to monoamine oxidase activity
Jazyk angličtina Země Anglie, Velká Británie Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
PubMed
26944656
DOI
10.1016/j.pnpbp.2016.02.012
PII: S0278-5846(16)30027-6
Knihovny.cz E-zdroje
- Klíčová slova
- Hybrid drug, Mental disorder, Monoamine oxidase, Monoamine oxidase inhibitor, Neuroprotection,
- MeSH
- duševní poruchy farmakoterapie enzymologie MeSH
- inhibitory MAO chemická syntéza farmakologie terapeutické užití MeSH
- lidé MeSH
- monoaminoxidasa metabolismus MeSH
- nervový přenos účinky léků fyziologie MeSH
- neurodegenerativní nemoci farmakoterapie enzymologie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- inhibitory MAO MeSH
- monoaminoxidasa MeSH
Progress in understanding the role of monoamine neurotransmission in pathophysiology of neuropsychiatric disorders was made after the discovery of the mechanisms of action of psychoactive drugs, including monoamine oxidase (MAO) inhibitors. The increase in monoamine neurotransmitter availability, decrease in hydrogen peroxide production, and neuroprotective effects evoked by MAO inhibitors represent an important approach in the development of new drugs for the treatment of mental disorders and neurodegenerative diseases. New drugs are synthesized by acting as multitarget-directed ligands, with MAO, acetylcholinesterase, and iron chelation as targets. Basic information is summarized in this paper about the drug-induced regulation of monoaminergic systems in the brain, with a focus on MAO inhibition. Desirable effects of MAO inhibition include increased availability of monoamine neurotransmitters, decreased oxidative stress, decreased formation of neurotoxins, induction of pro-survival genes and antiapoptotic factors, and improved mitochondrial functions.
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