OBJECTIVE: To quantify the periventricular venous density in neuromyelitis optica spectrum disease (NMOSD) in comparison to that in patients with multiple sclerosis (MS) and healthy control subjects. MATERIALS AND METHODS: Sixteen patients with NMOSD, 16 patients with MS and 16 healthy control subjects underwent 7.0-Tesla (7T) MRI. The imaging protocol included T2*-weighted (T2*w) fast low angle-shot (FLASH) and fluid-attenuated inversion recovery (FLAIR) sequences. The periventricular venous area (PVA) was manually determined by a blinded investigator in order to estimate the periventricular venous density in a region of interest-based approach. RESULTS: No significant differences in periventricular venous density indicated by PVA were detectable in NMOSD versus healthy controls (p = 0.226). In contrast, PVA was significantly reduced in MS patients compared to healthy controls (p = 0.013). CONCLUSION: Unlike patients with MS, those suffering from NMOSD did not show reduced venous visibility. This finding may underscore primary and secondary pathophysiological differences between these two distinct diseases of the central nervous system.

Berlin Ultrahigh Field Facility Max Delbrück Center for Molecular Medicine Berlin Germany

Clinical and Experimental Multiple Sclerosis Research Center Charité Universitätsmedizin Berlin Berlin Germany

Department of Neurology and Center of Clinical Neuroscience 1st Faculty of Medicine General University Hospital Prague Charles University Prague Prague Czech Republic

Department of Neurology Asklepios Fachklinikum Teupitz Teupitz Germany

Department of Neurology Charité Universitätsmedizin Berlin Berlin Germany

Department of Neurology Multiple Sclerosis Care Center NYU School of Medicine New York NY USA

Department of Neurology Universitätsspital Basel Basel Switzerland

Department of Radiology NYU School of Medicine New York NY USA

Experimental and Clinical Research Center Charité Universitätsmedizin Berlin and Max Delbrück Center for Molecular Medicine Berlin Germany

Institute of Neuroradiology Universitätsmedizin Göttingen Göttingen Germany

Medical Image Analysis Center AG Basel Switzerland

NeuroCure Clinical Research Center Charité Universitätsmedizin Berlin Berlin Germany

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