Adenoid cystic carcinoma (AdCC) of the head and neck is a well-recognized pathologic entity that rarely occurs in the larynx. Although the 5-year locoregional control rates are high, distant metastasis has a tendency to appear more than 5 years post treatment. Because AdCC of the larynx is uncommon, it is difficult to standardize a treatment protocol. One of the controversial points is the decision whether or not to perform an elective neck dissection on these patients. Because there is contradictory information about this issue, we have critically reviewed the literature from 1912 to 2015 on all reported cases of AdCC of the larynx in order to clarify this issue. During the most recent period of our review (1991-2015) with a more exact diagnosis of the tumor histology, 142 cases were observed of AdCC of the larynx, of which 91 patients had data pertaining to lymph node status. Eleven of the 91 patients (12.1%) had nodal metastasis and, based on this low proportion of patients, routine elective neck dissection is therefore not recommended.

Coordinator of the International Head and Neck Scientific Group Padua Italy

Department of Anatomic Pathology Hospital Clinic University of Barcelona Barcelona Spain

Department of Biomedical Sciences and Medicine University of Algarve Faro Portugal

Department of Head and Neck Surgery and Otorhinolaryngology A C Camargo Cancer Center São Paulo Brazil

Department of Head and Neck Surgery Head and Neck Oncology Program St Luc University Hospital and King Albert 2 Cancer Institute Brussels Belgium

Department of Head and Neck Surgical Oncology UMC Utrecht Cancer Center University Medical Center Utrecht Utrecht The Netherlands

Department of Otolaryngology Head and Neck Surgery Neurological Institute of New Jersey Rutgers New Jersey Medical School Newark NJ USA

Department of Otolaryngology Head and Neck Surgery Nottingham University Hospitals Queens Medical Centre Campus Nottingham UK

Department of Otolaryngology Head and Neck Surgery Philipp University Marburg Germany

Department of Otolaryngology Head and Neck Surgery Radboud University Medical Center Nijmegen The Netherlands

Department of Otolaryngology Hospital Universitario Central de Asturias Oviedo Spain

Department of Otorhinolaryngology The University of Oklahoma Health Sciences Center Oklahoma City OK USA

Department of Pathology Allegiance Health Jackson MI USA

Department of Pathology Beth Israel Medical Center New York NY USA

Department of Pathology Faculty of Medicine in Plzen Charles University Prague Plzen Czech Republic

Department of Pathology Radboud University Medical Center Nijmegen The Netherlands

Department of Pathology The University of Texas MD Anderson Cancer Center Houston TX USA

Department of Pathology University of Pittsburgh School of Medicine Pittsburgh PA USA

Department of Radiation Oncology Institute of Oncology Ljubljana Slovenia

Department of Radiation Oncology University of Florida Gainesville FL USA

Department of Surgery Banner MD Anderson Cancer Center Gilbert AZ USA

Departments of Pathology and Otolaryngology Head and Neck Surgery The Johns Hopkins Medical Institutions Baltimore MD USA

Departments of Surgery and Otolaryngology Head and Neck Surgery Albert Einstein College of Medicine Montefiore Medical Center Bronx NY USA

Division of Otolaryngology Head and Neck Surgery Southern Illinois University School of Medicine Springfield IL USA

European Salivary Gland Society Geneva Switzerland

Fundación de Investigación e Innovación Biosanitaria del Principado de Asturias Oviedo Spain

Head and Neck Surgery Memorial Sloan Kettering Cancer Center New York NY USA

Instituto Universitario de Oncología del Principado de Asturias University of Oviedo Oviedo Spain

Oral and Maxillofacial Pathology School of Dentistry University of Liverpool and Cellular Pathology Liverpool Clinical Laboratories Liverpool UK

Otorhinolaryngology Head and Neck Surgery and Department of Oncology Section Head and Neck Oncology University Hospitals Leuven KU Leuven Leuven Belgium

Southern California Permanente Medical Group Woodland Hills CA USA

University of Udine School of Medicine Udine Italy

University Pathologists Fall River MA USA

University Pathologists Providence RI USA

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