Novel chitin/chitosan-glucan wound dressing: Isolation, characterization, antibacterial activity and wound healing properties
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články
PubMed
27265311
DOI
10.1016/j.ijpharm.2016.06.003
PII: S0378-5173(16)30479-3
Knihovny.cz E-zdroje
- Klíčová slova
- Chitin/chitosan-glucan complex, Nonwoven mat, Surgical wound healing,
- MeSH
- antibakteriální látky aplikace a dávkování chemie MeSH
- buňky NIH 3T3 MeSH
- chitosan aplikace a dávkování chemie izolace a purifikace MeSH
- glukany aplikace a dávkování chemie izolace a purifikace MeSH
- hojení ran účinky léků MeSH
- krysa rodu Rattus MeSH
- myši MeSH
- obvazy * MeSH
- proliferace buněk účinky léků MeSH
- Schizophyllum izolace a purifikace MeSH
- vztah mezi dávkou a účinkem léčiva MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- antibakteriální látky MeSH
- chitosan MeSH
- glukany MeSH
Chitin/chitosan-glucan complex (ChCsGC) was isolated from Schizophyllum commune (S. commune) and dissolved for the first time in precooled (-15°C) 8wt.% urea/6wt.% NaOH aqueous solution. Novel nonwoven microfiber mats were fabricated by wet-dry-spinning technique and evaluated the mechanical of fabrics mats and surface morphology. Isolated and nonwoven mat were characterized employing FTIR-ATR, Optical microscope, TGA, DSC, H/C NMR, SEM and XRD techniques. According to the physical/chemical characterization measurements we can assumed that, the net and the novel dressing mats have the same chemical structure with slightly changes in the thermal stability for the dressing mats.The biological activity of the nonwoven ChCsGC fabric was tested against different types of bacteria exhibiting excellent antibacterial activity. Cell viability of the plain complex and nonwovens mats were evaluated utilizing mouse fibroblast cell line varying concentrations and treatment time. ChCsGC did not show any cytotoxicity against mouse fibroblast cells and the cell-fabrics interaction was also investigated using fluorescence microscope. The novel ChCsGC nonwovens exhibited excellent surgical wound healing ability when tested using rat models.
CEITEC Central European Institute of Technology Brno University of Technology Brno Czech Republic
Zoology Department Faculty of Science Fayoum University Fayoum Egypt
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