Circulating Growth and Angiogenic Factors and Lymph Node Status in Early-stage Breast Cancer - A Pilot Study
Language English Country Greece Media print
Document type Journal Article
PubMed
27466533
PII: 36/8/4209
Knihovny.cz E-resources
- Keywords
- Breast cancer, IGF1, VEGF, axillary lymph node dissection, biomarkers, lymph node status,
- MeSH
- Axilla MeSH
- Carcinoma, Ductal, Breast blood diagnosis secondary MeSH
- Insulin-Like Growth Factor Binding Protein 3 blood MeSH
- Insulin-Like Growth Factor I metabolism MeSH
- Middle Aged MeSH
- Humans MeSH
- Lymphatic Metastasis MeSH
- Lymph Nodes pathology MeSH
- Biomarkers, Tumor blood MeSH
- Breast Neoplasms blood diagnosis pathology MeSH
- Osteopontin blood MeSH
- Pilot Projects MeSH
- Case-Control Studies MeSH
- Vascular Endothelial Growth Factor A blood MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- IGF1 protein, human MeSH Browser
- Insulin-Like Growth Factor Binding Protein 3 MeSH
- IGFBP3 protein, human MeSH Browser
- Insulin-Like Growth Factor I MeSH
- Biomarkers, Tumor MeSH
- Osteopontin MeSH
- SPP1 protein, human MeSH Browser
- Vascular Endothelial Growth Factor A MeSH
- VEGFA protein, human MeSH Browser
AIM: To evaluate the possibility of selected biomarkers for breast cancer diagnostics and/or treatment monitoring, lymph node (LN) status determination and clinical decision regarding axillary node dissection. PATIENTS AND METHODS: Two hundred and eleven patients with malignant breast cancer and 42 age-matched healthy controls were enrolled. Serum insulin-like growth factor 1 (IGF1) and insulin-like growth factor binding protein 3 (IGFBP3) and plasma epidermal growth factor (EGF), vascular endothelial growth factor (VEGF), osteoprotegerin (OPG) and osteopontin (OPN) were measured. We compared patients versus controls, patients with negative versus positive lymph node and patients with and without axillary lymph node dissection (ALND). RESULTS: We found elevated IGF1 and VEGF levels in patients with lymph node metastases compared to controls (p=0.0179 and p=0.0091, respectively) and in patients with ALND (p=0.0337 and p=0.0438, respectively). CONCLUSION: Circulating IGF1 and VEGF levels may predict the presence of lymph node metastases and help in the decision to avoid ALND in patients with early-stage breast cancer.
