Psoriasis is a lifelong chronic inflammatory disease affecting 2-3% of the worldwide population. Scalp psoriasis is a particular form of psoriasis characterized by lesions on the scalp, which may occur isolated or in association with other skin lesions. The aim of this study was to investigate the efficacy and safeness of an innovative treatment of scalp psoriasis, which is based on the topical application of natural products. Fifty adult subjects with scalp psoriasis (23 females, 27 males) from different European dermatological centres were included in the study. Forty-six patients with severely infiltrated psoriatic lesions were invited to use the products of Dr Michaels® (Soratinex®), according to a three-phase application, twice a day (morning and evening). The other 4 patients followed a different regimen: after a shampoo in the evening, they applied the conditioner in the night and washed it in the morning with the cleansing gel. The application time of Dr Michaels® (Soratinex®) products was 8 weeks. The treatment was evaluated at 0, 1, 2, 3, 4, 5, 6, 7, and 8 weeks. The evaluation was based on the Psoriasis Scalp Severity Index (PSSI) and on a photographic analysis at each of the medical evaluation points. At the end of the study, all patients showed an outstanding improvement. Five patients referred a transient pruritus, which regressed spontaneously without discontinuing the application. No other side effects have been described. We observe that Dr Michaels® (Soratinex®) natural product family can be considered as a valid therapeutic tool for scalp psoriasis when considering the exclusion criteria. The tested products provided an outstanding improvement of lesions in all the patients, without side effects.

2nd Medical Faculty Charles University Bulovka Hospital Institute of Clinical and Experimental Medicine Prague Czech Republic

Chair of Dermatology University of Rome “G Marconi” Rome Italy

Department “Medicinal Information and Non interventional studies” Bulgarian Drug Agency Sofia Bulgaria

Department of Dermatology and Allergology Academic Teaching Hospital Dresden Friedrichstadt Dresden Germany

Department of Dermatology and Cutaneous Surgery Department of Psychiatry and Behavioral Sciences Institute for Bioethics and Health Policy University of Miami Miller School of Medicine Miami FL USA; Centro Studi per la Ricerca Multidisciplinare e Rigenerativa Università Degli Studi G Marconi Rome Italy

Department of Nuclear Physics Sub nuclear and Radiation G Marconi University Rome Italy

Dermatological Department University of Pisa Pisa Italy

Medical Institute of Ministry of Interior Department of Dermatology Venereology and Dermatologic Surgery Sofia Bulgaria

”Onkoderma” Policlinic for dermatology and dermatologic surgery Sofia Bulgaria; Department of Dermatology and Venereology Medical University of Plovdiv Medical faculty Plovdiv Bulgaria

PRO SANUM Ltd Sanatorium of Prof Novotný Štěpánská Prague 1 Czech Republic

Psoriasis and Skin Clinic Melbourne Australia

University B 1 S Group of Institutions Punjab Technical University Punjab India