Prognostic Significance of TMPRSS2-ERG Fusion Gene in Prostate Cancer
Jazyk angličtina Země Řecko Médium print
Typ dokumentu časopisecké články
PubMed
27630329
DOI
10.21873/anticanres.11037
PII: 36/9/4787
Knihovny.cz E-zdroje
- Klíčová slova
- PCA3, PSA, Prostate cancer, TMPRSS2-ERG, microRNA, prognosis,
- MeSH
- antigeny nádorové biosyntéza genetika MeSH
- dospělí MeSH
- fúzní onkogenní proteiny genetika MeSH
- lidé středního věku MeSH
- lidé MeSH
- lokální recidiva nádoru krev genetika patologie MeSH
- mikro RNA biosyntéza genetika MeSH
- nádorové biomarkery biosyntéza krev genetika MeSH
- nádory prostaty krev genetika patologie chirurgie MeSH
- prediktivní hodnota testů MeSH
- prognóza MeSH
- proporcionální rizikové modely MeSH
- prostata patologie MeSH
- prostatektomie MeSH
- prostatický specifický antigen krev MeSH
- regulace genové exprese u nádorů MeSH
- rizikové faktory MeSH
- senioři MeSH
- zalévání tkání do parafínu MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- antigeny nádorové MeSH
- fúzní onkogenní proteiny MeSH
- mikro RNA MeSH
- MIRN221 microRNA, human MeSH Prohlížeč
- MIRN23a microRNA, human MeSH Prohlížeč
- MIRN26A microRNA, human MeSH Prohlížeč
- nádorové biomarkery MeSH
- prostate cancer antigen 3, human MeSH Prohlížeč
- prostatický specifický antigen MeSH
- TMPRSS2-ERG fusion protein, human MeSH Prohlížeč
BACKGROUND/AIM: Current research of prostate cancer (PCa) offers a promising way of identifying patients with adverse prognosis who do benefit from radical treatment that can affect quality of life as resections are associated with numerous side-effects. The aim of our study was to evaluate the relationship of TMPRSS2-ERG fusion gene status, tumor tissue prostate-specific antigen (PSA), prostate cancer antigen 3 (PCA3), miR-23b, miR-26a and miR-221 expression levels in combination with preoperative serum PSA level to the risk of PCa recurrence after radical prostatectomy. PATIENTS AND METHODS: The study group consisted of 108 patients who underwent radical prostatectomy. PSA was measured in peripheral blood collected preoperativelly. The expression of TMPRSS2-ERG transcript and the expression of miR-23b, miR-26a and miR-221 in formalin-fixed, paraffin-embedded (FFPE) tumor tissues was analyzed by reverse transcription (RT) real-time polymerase chain reaction (PCR). RESULTS: Significantly shorter time to recurrence was observed in patients with high expression of TMPRSS2-ERG (p=0.0020). High levels of preoperative PSA (>10.0 ng/ml) proved to be marker of shorter time to recurrence (p=0.0153). The most promising marker of the risk of recurrence after radical prostatectomy was a combination of high level of preoperative serum PSA and high expression of TMPRSS2-ERG fusion transcript in tumor tissue (p=0.0001). CONCLUSION: A combination of high preoperative serum PSA and high expression of TMPRSS2-ERG could be promising in distinguishing those tumors that are aggressive and life-threatening.
Department of Biology Faculty of Medicine in Pilsen Charles University Prague Pilsen Czech Republic
Department of Urology Faculty of Medicine in Pilsen Charles University Prague Pilsen Czech Republic
Institute of Microbiology v v i Academy of Sciences of the Czech Republic Prague Czech Republic
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