Impact of acute and chronic inhalation exposure to CdO nanoparticles on mice
Jazyk angličtina Země Německo Médium print-electronic
Typ dokumentu časopisecké články
PubMed
27638805
DOI
10.1007/s11356-016-7600-6
PII: 10.1007/s11356-016-7600-6
Knihovny.cz E-zdroje
- Klíčová slova
- Accumulation, Cadmium, Glutathione, Lipid peroxidation, Nanoparticle, Oxidative stress, Tissue damage,
- MeSH
- glutathion metabolismus MeSH
- inhalační expozice škodlivé účinky MeSH
- játra účinky léků metabolismus patologie MeSH
- ledviny účinky léků metabolismus patologie MeSH
- myši inbrední ICR MeSH
- myši MeSH
- nanočástice toxicita MeSH
- oxidační stres MeSH
- oxidy toxicita MeSH
- peroxidace lipidů MeSH
- plíce účinky léků metabolismus patologie MeSH
- sloučeniny kadmia toxicita MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- cadmium oxide MeSH Prohlížeč
- glutathion MeSH
- oxidy MeSH
- sloučeniny kadmia MeSH
Cadmium nanoparticles can represent a risk in both industrial and environmental settings, but there is little knowledge on the impacts of their inhalation, especially concerning longer-term exposures. In this study, mice were exposed to cadmium oxide (CdO) nanoparticles in whole body inhalation chambers for 4 to 72 h in acute and 1 to 13 weeks (24 h/day, 7 days/week) in chronic exposure to investigate the dynamics of nanoparticle uptake and effects. In the acute experiment, mice were exposed to 2.95 × 106 particles/cm3 (31.7 μg CdO/m3). The same concentration and a lower one (1.18 × 106 particles/cm3, 12.7 μg CdO/m3) were used for the chronic exposure. Transmission electron microscopy documented distribution of nanoparticles into all studied organs. Major portion of nanoparticles was retained in the lung, but longer exposure led to a greater relative redistribution into secondary organs, namely the kidney, and also the liver and spleen. Accumulation of Cd in the lung and liver occurred already after 24 h and in the brain, kidney, and spleen after 72 h of exposure, and a further increase of Cd levels was observed throughout the chronic exposure. There were significant differences in both Cd accumulation and effects between the two exposure doses. Lung weight in the higher exposure group increased up to 2-fold compared to the control. Histological analyses showed dose-dependent alterations in lung and liver morphology and damage to their tissue. Modulation of oxidative stress parameters including glutathione levels and increased lipid peroxidation occurred mainly after the greater chronic exposure. The results emphasize risk of longer-term inhalation of cadmium nanoparticles, since adverse effects occurring after shorter exposures gradually progressed with a longer exposure duration.
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