Current mass spectrometry, nuclear magnetic resonance spectroscopy, and X-ray diffraction are presented as structure elucidation tools for analytical chemistry of natural products. Discovering new molecular entities combined with dereplication of known organic compounds represent prerequisites for biological assays and for respective applications as pharmaceuticals or molecular markers. Liquid chromatography is briefly addressed with respect to its use in mass spectrometry- and nuclear magnetic resonance-based metabolomics studies.

Institute of Microbiology Academy of Sciences of the Czech Republic Videnska 1083 Prague 4 Czech Republic

Regional Centre of Advanced Technologies and Materials Department of Analytical Chemistry Palacky University 17 listopadu 12 77146 Olomouc Czech Republic

The University of Texas at Arlington Department of Chemistry and Biochemistry Arlington Texas 76019 0065 United States

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