Functional improvement after successful catheter ablation for long-standing persistent atrial fibrillation
Jazyk angličtina Země Velká Británie, Anglie Médium print
Typ dokumentu časopisecké články
PubMed
27707782
DOI
10.1093/europace/euw282
PII: euw282
Knihovny.cz E-zdroje
- Klíčová slova
- Atrial fibrillation, Catheter ablation, Long-standing persistent, Outcome,
- MeSH
- antiarytmika terapeutické užití MeSH
- biologické markery krev MeSH
- časové faktory MeSH
- dospělí MeSH
- fibrilace síní diagnóza patofyziologie chirurgie MeSH
- funkce levé komory srdeční * MeSH
- katetrizační ablace * škodlivé účinky MeSH
- kvalita života MeSH
- lidé středního věku MeSH
- lidé MeSH
- multivariační analýza MeSH
- natriuretický peptid typu B krev MeSH
- obnova funkce MeSH
- peptidové fragmenty krev MeSH
- prospektivní studie MeSH
- průzkumy a dotazníky MeSH
- registrace MeSH
- rizikové faktory MeSH
- rozdělení chí kvadrát MeSH
- senioři MeSH
- sexuální faktory MeSH
- spotřeba kyslíku MeSH
- srdce - funkce levé síně * MeSH
- tepový objem MeSH
- tolerance zátěže * MeSH
- věkové faktory MeSH
- výsledek terapie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- antiarytmika MeSH
- biologické markery MeSH
- natriuretický peptid typu B MeSH
- peptidové fragmenty MeSH
- pro-brain natriuretic peptide (1-76) MeSH Prohlížeč
AIMS: Identifying patients who benefit from restored sinus rhythm (SR) would optimize the selection of candidates for ablation of long-standing persistent atrial fibrillation (LSPAF). This prospective study sought to identify the hitherto unknown factors associated with global functional improvement after successful radiofrequency catheter ablation of LSPAF. METHODS AND RESULTS: In 171 LSPAF patients (84% of the total consecutive 203 patients) who were examined in SR 12 months after ablation, the individual per cent change from baseline value in maximum oxygen consumption at exercise test (VO2 max), left ventricular ejection fraction (LVEF), N-terminal prohormone of brain natriuretic peptide (NT-proBNP), and five-dimensional descriptive system (EQ-5D) of quality-of-life questionnaire were classified in quartiles by 0 (worse) to 3 (best) grades. The individual grades were summed into a composite score (SCORE, 0 … 12) reflecting global functional improvement. Significant improvement in VO2 max (3.4 ± 4.7 mL/kg/min), LVEF (7.5 ± 9.1%), NT-proBNP (-861 ± 809 pg/mL), and EQ-5D (0.7 ± 0.12) was observed (all P < 0.0001). On multivariable analysis, younger age (P = 0.001), male gender (P = 0.02), timely post-ablation left atrial appendage (LAA) outflow (P = 0.005) with improvement in outflow velocity (P = 0.0002), and withdrawal of Class I/III antiarrhythmic drugs (P < 0.05) were positively and independently correlated with the SCORE. CONCLUSIONS: Younger male patients benefited most from catheter ablation of LSPAF. Delayed or non-improved LAA outflow and inability to discontinue Class I/III antiarrhythmic medication reduced the post-ablation functional improvement.
Department of Cardiology Hospital Podlesí Trinec Czech Republic
Department of Cardiology Hospital Podlesí Třinec Czech Republic
Department of Cardiology Institute for Clinical and Experimental Medicine Prague Czech Republic
Citace poskytuje Crossref.org
Catheter Ablation for Persistent and Long-Standing Persistent Atrial Fibrillation
