Hyaluronic Acid and Its Derivatives in Coating and Delivery Systems: Applications in Tissue Engineering, Regenerative Medicine and Immunomodulation
Language English Country Germany Media print-electronic
Document type Journal Article, Review, Research Support, Non-U.S. Gov't
- Keywords
- biomedical, coatings, delivery systems, hyaluronic acid, immunomodulation, tissue engineering,
- MeSH
- Biocompatible Materials administration & dosage MeSH
- Wound Healing drug effects MeSH
- Hydrogels administration & dosage MeSH
- Immunomodulation drug effects MeSH
- Hyaluronic Acid administration & dosage MeSH
- Drug Delivery Systems methods MeSH
- Humans MeSH
- Regenerative Medicine methods MeSH
- Tissue Engineering methods MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Biocompatible Materials MeSH
- Hydrogels MeSH
- Hyaluronic Acid MeSH
As an Extracellular Matrix (ECM) component, Hyaluronic acid (HA) plays a multi-faceted role in cell migration, proliferation and differentiation at micro level and system level events such as tissue water homeostasis. Among its biological functions, it is known to interact with cytokines and contribute to their retention in ECM microenvironment. In addition to its biological functions, it has advantageous physical properties which result in the industrial endeavors in the synthesis and extraction of HA for variety of applications ranging from medical to cosmetic. Recently, HA and its derivatives have been the focus of active research for applications in biomedical device coatings, drug delivery systems and in the form of scaffolds or cell-laden hydrogels for tissue engineering. A specific reason for the increase in use of HA based structures is their immunomodulatory and regeneration inducing capacities. In this context, this article reviews recent literature on modulation of the implantable biomaterial microenvironment by systems based on HA and its derivatives, particularly hydrogels and microscale coatings that are able to deliver cytokines in order to reduce the adverse immune reactions and promote tissue healing.
Contipro Biotech S R O Dolni Dobrouc 401 561 02 Dolni Dobrouc Czech Republic
Inserm UMR 1121 11 rue Humann 67085 Strasbourg France
Institut Charles Sadron CNRS UPR 22 23 rue du Lœss 67034 Strasbourg France
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