Effect of Riboflavin/UVA Collagen Cross-linking on Central Cornea, Limbus and Intraocular Pressure. Experimental Study in Rabbit Eyes
Language English Country Czech Republic Media print
Document type Journal Article
PubMed
27770837
DOI
10.14712/18059694.2016.96
PII: am_2016059030091
Knihovny.cz E-resources
- Keywords
- Cornea, Corneal Crosslinking, Intraocular pressure, Limbus,
- MeSH
- Photosensitizing Agents pharmacology MeSH
- Collagen chemistry ultrastructure MeSH
- Rabbits MeSH
- Limbus Corneae drug effects radiation effects surgery ultrastructure MeSH
- Intraocular Pressure * drug effects radiation effects MeSH
- Cross-Linking Reagents pharmacology MeSH
- Riboflavin pharmacology MeSH
- Cornea drug effects radiation effects surgery ultrastructure MeSH
- Ultraviolet Rays * MeSH
- Animals MeSH
- Check Tag
- Rabbits MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Photosensitizing Agents MeSH
- Collagen MeSH
- Cross-Linking Reagents MeSH
- Riboflavin MeSH
The Purpose of present study was to investigate the effect of riboflavin/ultraviolet-A-induced collagen cross-linking (CXL) on central cornea, limbus and intraocular pressure (IOP). This was an animal experimental study. The right corneas of 10 rabbits were ultraviolet-A irradiated (3 mW/cm2 for 30 minutes) after de-epithelialization and instillation of 0.1% riboflavin / 20% Dextran drops. Left corneas served as controls. Samples were examined histologically one month postoperatively. Before and after treatment, IOP measurements were recorded bilaterally. At central cornea of eyes underwent CXL keratocyte repopulation, normal arrangement of collagen fibres and a statistically significant change in fibres diameter were detected, compared to controls. At limbus area, there were not any significant histological differences after CXL. There was no statistically significant difference between pre- and postoperative IOP in all eyes.
1st University Department of Ophthalmology Aristotle University of Thessaloniki Thessaloniki Greece
Department of Pathology Democritus University of Thrace Alexandroupolis Greece
Eye Institute of Thrace Democritus University of Thrace Alexandroupolis Greece
Institut Carnot de Bourgogne University of Burgundy Bourgogne France
Institute of Vision and Optics University of Crete Heraklion Greece
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