Cerebellum-from J. E. Purkyně up to Contemporary Research
Language English Country United States Media print
Document type Journal Article, Review, Research Support, Non-U.S. Gov't
PubMed
27858255
DOI
10.1007/s12311-016-0835-4
PII: 10.1007/s12311-016-0835-4
Knihovny.cz E-resources
- Keywords
- Animal models, Ataxia, Cerebellar degeneration, Cerebellum, Neurodegeneration, Purkinje cells, SCA models,
- MeSH
- Cerebellar Cortex physiopathology MeSH
- Humans MeSH
- Models, Animal MeSH
- Cerebellum physiopathology MeSH
- Cerebellar Diseases physiopathology MeSH
- Purkinje Cells physiology MeSH
- Research * MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
Jan. Evangelista Purkyně, the most famous among Czech physiologists, was the first who identified and described the largest nerve cells in the cerebellum. The most distinguished researchers of the nervous system then recommended naming these neurons Purkinje cells in his honor. Through experiments by Purkinje and his followers, the function of the cerebellum was properly attributed to the precision of motor movements and skills. This traditional concept was valid until early 1990s, when it was readjusted and replenished with new and important findings. It was discovered that the cerebellar cortex contains more neurons than the cerebral cortex and shortly thereafter was gradually revealed that such enormous numbers of neural cells are not without impact on brain functions. It was shown that the cerebellum, in addition to its traditional role, also participates in higher nervous activity. These new findings were obtained thanks to the introduction of modern methods of examination into the clinical praxis, and experimental procedures using animal models of cerebellar disorders described in this work.
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