Serum Concentration of Erlotinib and its Correlation with Outcome and Toxicity in Patients with Advanced-stage NSCLC
Jazyk angličtina Země Řecko Médium print
Typ dokumentu časopisecké články
PubMed
29061834
DOI
10.21873/anticanres.12102
PII: 37/11/6469
Knihovny.cz E-zdroje
- Klíčová slova
- Erlotinib, NSCLC, diarrhoea, lung cancer, serum concentration, skin rash, survival, toxicity,
- MeSH
- analýza přežití MeSH
- erbB receptory genetika MeSH
- erlotinib škodlivé účinky krev terapeutické užití MeSH
- exantém chemicky indukované MeSH
- lidé MeSH
- nádory plic krev farmakoterapie genetika MeSH
- nemalobuněčný karcinom plic krev farmakoterapie genetika MeSH
- přežití bez známek nemoci MeSH
- protinádorové látky škodlivé účinky krev terapeutické užití MeSH
- průjem chemicky indukované MeSH
- retrospektivní studie MeSH
- staging nádorů MeSH
- výsledek terapie MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- EGFR protein, human MeSH Prohlížeč
- erbB receptory MeSH
- erlotinib MeSH
- protinádorové látky MeSH
BACKGROUND: Erlotinib is a tyrosine kinase inhibitor targeting epidermal growth factor receptor (EGFR); it is used in the treatment of advanced non-small cell lung cancer (NSCLC). We focused on the role of serum concentration of erlotinib and its association with outcome and toxicity in patients with advanced NSCLC harbouring the wild-type EGFR gene or squamous histology. PATIENTS AND METHODS: Clinical data of 122 patients were analyzed. Serum samples were collected within four weeks after the initiation of treatment. RESULTS: There was no significant association of erlotinib concentration with PFS nor OS (p=0.352 and p=0.6393). Significant associations of erlotinib concentration with grade of skin rash and diarrhoea (p<0.0001 and p<0.0001) were found. Skin rash and diarrhoea were significantly associated with PFS (p=0.0338 and p=0.0001) and OS (p=0.0064 and p=0.0353). CONCLUSION: Erlotinib concentration was not associated with outcome. Erlotinib concentration was associated with occurrence and severity of skin rash and diarrhoea; the outcome was associated with erlotinib toxicity.
Biomedical Center Faculty of Medicine in Pilsen Charles University Pilsen Czech Republic
Center for Applied Genomics of Solid Tumours Genomac Research Institute Prague Czech Republic
Department of Analytical Chemistry Faculty of Sciences Charles University Prague Czech Republic
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