Increased Binding of Calcium Ions at Positively Curved Phospholipid Membranes
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články
- MeSH
- fosfolipidy chemie MeSH
- ionty chemie MeSH
- lipidové dvojvrstvy chemie MeSH
- liposomy chemie MeSH
- membrány umělé MeSH
- membrány MeSH
- simulace molekulární dynamiky MeSH
- vápník chemie MeSH
- voda chemie MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- fosfolipidy MeSH
- ionty MeSH
- lipidové dvojvrstvy MeSH
- liposomy MeSH
- membrány umělé MeSH
- vápník MeSH
- voda MeSH
Calcium ion is the ubiquitous messenger in cells and plays a key role in neuronal signaling and fusion of synaptic vesicles. These vesicles are typically ∼20-50 nm in diameter, and thus their interaction with calcium ions cannot be modeled faithfully with a conventional flat membrane bilayer setup. Within our newly developed molecular dynamics simulations setup, we characterize here interactions of the calcium ion with curved membrane interfaces with atomistic detail. The present molecular dynamics simulations together with time-dependent fluorescence shift experiments suggest that the mode and strength of interaction of calcium ion with a phospholipid bilayer depends on its curvature. Potential of mean force calculations demonstrate that the binding of calcium ion to the positively curved side of the bilayer is significantly stronger compared with that to a flat membrane.
Department of Physics Tampere University of Technology P O Box 692 FI 33101 Tampere Finland
Faculty of Pharmacy University of Helsinki Viikinkaari 5E Helsinki 00014 Finland
Institut für Physikalische und Theoretische Chemie Universität Regensburg 93040 Regensburg Germany
Citace poskytuje Crossref.org
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