INCREASED SERUM LEVELS OF UREA AND CREATININE ARE SURROGATE MARKERS FOR DISRUPTION OF RETINAL PHOTORECEPTOR EXTERNAL LIMITING MEMBRANE AND INNER SEGMENT ELLIPSOID ZONE IN TYPE 2 DIABETES MELLITUS
Language English Country United States Media print
Document type Journal Article
PubMed
28118284
DOI
10.1097/iae.0000000000001163
PII: 00006982-201702000-00015
Knihovny.cz E-resources
- MeSH
- Analysis of Variance MeSH
- Biomarkers blood MeSH
- Diabetes Mellitus, Type 2 blood pathology MeSH
- Diabetic Retinopathy blood pathology physiopathology MeSH
- Adult MeSH
- Epiretinal Membrane pathology MeSH
- Photoreceptor Cells, Vertebrate pathology MeSH
- Creatinine blood MeSH
- Middle Aged MeSH
- Humans MeSH
- Urea blood MeSH
- Retinal Diseases MeSH
- Aged MeSH
- Case-Control Studies MeSH
- Severity of Illness Index MeSH
- Retinal Photoreceptor Cell Inner Segment pathology MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Biomarkers MeSH
- Creatinine MeSH
- Urea MeSH
PURPOSE: To evaluate the role of serum urea and creatinine as surrogate markers for disruption of retinal photoreceptor external limiting membrane (ELM) and inner segment ellipsoid zone (EZ) in Type 2 diabetic retinopathy (DR) using spectral-domain optical coherence tomography, for the first time. METHODS: One hundred and seventeen consecutive cases of Type 2 diabetes mellitus (diabetes without retinopathy [No DR; n = 39], nonproliferative diabetic retinopathy [NPDR; n = 39], proliferative diabetic retinopathy [PDR; n = 39]) and 40 healthy control subjects were included. Serum levels of urea and creatinine were assessed using standard protocol. Spectral-domain optical coherence tomography was used to grade the disruption of ELM and EZ as follows: Grade 0, no disruption of ELM and EZ; Grade 1, ELM disrupted, EZ intact; Grade 2, ELM and EZ disrupted. Data were analyzed statistically. RESULTS: Increase in serum levels of urea (F = 22.93) and creatinine (F = 15.82) and increased grades of disruption of ELM and EZ (γ = 116.3) were observed with increased severity of DR (P < 0.001). Increase in serum levels of urea (F = 10.45) and creatinine (F = 6.89) was observed with increased grades of disruption of ELM and EZ (P = 0.001). CONCLUSION: Serum levels of urea and creatinine are surrogate markers for disruption of retinal photoreceptor ELM and EZ on spectral-domain optical coherence tomography in DR.
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