Chronic dietary exposure to branched chain amino acids impairs glucose disposal in vegans but not in omnivores
Jazyk angličtina Země Velká Británie, Anglie Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
28145418
DOI
10.1038/ejcn.2016.274
PII: ejcn2016274
Knihovny.cz E-zdroje
- MeSH
- antropometrie MeSH
- cvičení MeSH
- dieta veganská MeSH
- dieta MeSH
- dietární expozice škodlivé účinky MeSH
- dietní proteiny aplikace a dávkování MeSH
- dospělí MeSH
- glykemický clamp MeSH
- inzulin krev MeSH
- inzulinová rezistence MeSH
- kosterní svaly účinky léků metabolismus MeSH
- krevní glukóza metabolismus MeSH
- lidé MeSH
- mladý dospělý MeSH
- prospektivní studie MeSH
- průzkumy a dotazníky MeSH
- vegani * MeSH
- větvené aminokyseliny aplikace a dávkování krev MeSH
- vztah mezi dávkou a účinkem léčiva MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- dietní proteiny MeSH
- inzulin MeSH
- krevní glukóza MeSH
- větvené aminokyseliny MeSH
BACKGROUND/OBJECTIVES: Branched chain amino acids (BCAA) are among nutrients strongly linked with insulin sensitivity (IS) measures. We investigated the effects of a chronic increase of BCAA intake on IS in two groups of healthy subjects differing in their basal consumption of BCAA, that is, vegans and omnivores. SUBJECTS/METHODS: Eight vegans and eight matched omnivores (five men and three women in each group) received 15 g (women) or 20 g (men) of BCAA daily for 3 months. Anthropometry, blood analyses, glucose clamp, arginine test, subcutaneous abdominal adipose tissue (AT) and skeletal muscle (SM) biopsies (mRNA levels of selected metabolic markers, respiratory chain (RC) activity) were performed at baseline, after the intervention and after a 6 month wash-out period. RESULTS: Compared with omnivores, vegans had higher IS at baseline (GIR, glucose infusion rate: 9.6±2.4 vs 7.1±2.4 mg/kg/min, 95% CI for difference: 0.55 to 5.82) that declined after the intervention and returned to baseline values after the wash-out period (changes in GIR with 95% CI, 3-0 months: -1.64 [-2.5; -0.75] and 9-3 months: 1.65 [0.75; 2.54] mg/kg/min). No such change was observed in omnivores. In omnivores the intervention led to an increased expression of lipogenic genes (DGAT2, FASN, PPARγ, SCD1) in AT. SM RC activity increased in both groups. CONCLUSIONS: Negative impact of increased BCAA intake on IS was only detected in vegans, that is, subjects with low basal amino acids/BCAA intake, which appear to be unable to induce sufficient compensatory changes within AT and SM on a BCAA challenge.
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