Changes in the oxidative stress/anti-oxidant system after exposure to sulfur mustard and antioxidant strategies in the therapy, a review
Jazyk angličtina Země Velká Británie, Anglie Médium print-electronic
Typ dokumentu časopisecké články, přehledy
- Klíčová slova
- Oxidative stress, antioxidant, bis(2-chloroethyl)sulfide, inflammation, mustard gas, poly(ADP-ribose) polymerase, sulfur mustard,
- MeSH
- antioxidancia chemie terapeutické užití MeSH
- chemické bojové látky toxicita MeSH
- lidé MeSH
- molekulární struktura MeSH
- otrava enzymologie prevence a kontrola MeSH
- oxidační stres účinky léků MeSH
- yperit toxicita MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
- Názvy látek
- antioxidancia MeSH
- chemické bojové látky MeSH
- yperit MeSH
Sulfur mustard, in a chemical name bis(2-chloroethyl) sulfide, is a chemical warfare agent. It is cytotoxic and blister forming once spread over the skin. Though exact molecular mechanism of sulfur mustard toxic action remains unknown, inflammation and oxidative stress development are considered as the most relevant pathological consequences. Applications of either low-molecular weight antioxidants or cofactors for enzymatic antioxidants are considered as suitable ways how to ameliorate the poisoning. In this article, survey of literature on countermeasures against sulfur mustard poisoning are given and evidence of oxidative stress role during sulfur mustard poisoning and availability of antioxidants for the therapy are discussed.
b Department of Geology and Pedology Mendel University in Brno Brno Czech Republic
c Central European Institute of Technology Brno University of Technology Brno Czech Republic
Faculty of Military Health Sciences University of Defense Hradec Kralove Czech Republic
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