An emergency brake for protein synthesis
Language English Country England, Great Britain Media electronic
Document type Journal Article, Comment
PubMed
28440747
PubMed Central
PMC5404913
DOI
10.7554/elife.27085
PII: e27085
Knihovny.cz E-resources
- Keywords
- ISR, S. cerevisiae, biochemistry, chromosomes, eIF2, eIF2B, genes, protein interactions, translational control,
- MeSH
- Eukaryotic Initiation Factor-2 genetics MeSH
- Eukaryotic Initiation Factor-2B genetics MeSH
- Phosphorylation MeSH
- Proteins MeSH
- Protein Biosynthesis MeSH
- Publication type
- Journal Article MeSH
- Comment MeSH
- Names of Substances
- Eukaryotic Initiation Factor-2 MeSH
- Eukaryotic Initiation Factor-2B MeSH
- Proteins MeSH
The integrated stress response is able to rapidly shut down the synthesis of proteins in eukaryotic cells.
See more in PubMed
Algire MA, Maag D, Lorsch JR. Pi release from eIF2, not GTP hydrolysis, is the step controlled by start-site selection during eukaryotic translation initiation. Molecular Cell. 2005;20:251–262. doi: 10.1016/j.molcel.2005.09.008. PubMed DOI
Chu J, Cargnello M, Topisirovic I, Pelletier J. Translation initiation factors: reprogramming protein synthesis in Cancer. Trends in Cell Biology. 2016;26:918–933. doi: 10.1016/j.tcb.2016.06.005. PubMed DOI
Hinnebusch AG. The scanning mechanism of eukaryotic translation initiation. Annual Review of Biochemistry. 2014;83:779–812. doi: 10.1146/annurev-biochem-060713-035802. PubMed DOI
Jennings MD, Kershaw CJ, Adomavicius T, Pavitt GD. Fail-safe control of translation initiation by dissociation of eIF2α phosphorylated ternary complexes. eLife. 2017;6:e24542. doi: 10.7554/eLife.24542. PubMed DOI PMC
Kapp LD, Lorsch JR. GTP-dependent recognition of the methionine moiety on initiator tRNA by translation factor eIF2. Journal of Molecular Biology. 2004;335:923–936. doi: 10.1016/j.jmb.2003.11.025. PubMed DOI
Pakos-Zebrucka K, Koryga I, Mnich K, Ljujic M, Samali A, Gorman AM. The integrated stress response. EMBO Reports. 2016;17:1374–1395. doi: 10.15252/embr.201642195. PubMed DOI PMC
Pavitt GD, Proud CG. Protein synthesis and its control in neuronal cells with a focus on vanishing white matter disease. Biochemical Society Transactions. 2009;37:1298–1310. doi: 10.1042/BST0371298. PubMed DOI