An emergency brake for protein synthesis
Jazyk angličtina Země Anglie, Velká Británie Médium electronic
Typ dokumentu časopisecké články, komentáře
PubMed
28440747
PubMed Central
PMC5404913
DOI
10.7554/elife.27085
PII: e27085
Knihovny.cz E-zdroje
- Klíčová slova
- ISR, S. cerevisiae, biochemistry, chromosomes, eIF2, eIF2B, genes, protein interactions, translational control,
- MeSH
- eukaryotický iniciační faktor 2 genetika MeSH
- eukaryotický iniciační faktor 2B genetika MeSH
- fosforylace MeSH
- proteiny MeSH
- proteosyntéza MeSH
- Publikační typ
- časopisecké články MeSH
- komentáře MeSH
- Názvy látek
- eukaryotický iniciační faktor 2 MeSH
- eukaryotický iniciační faktor 2B MeSH
- proteiny MeSH
The integrated stress response is able to rapidly shut down the synthesis of proteins in eukaryotic cells.
Zobrazit více v PubMed
Algire MA, Maag D, Lorsch JR. Pi release from eIF2, not GTP hydrolysis, is the step controlled by start-site selection during eukaryotic translation initiation. Molecular Cell. 2005;20:251–262. doi: 10.1016/j.molcel.2005.09.008. PubMed DOI
Chu J, Cargnello M, Topisirovic I, Pelletier J. Translation initiation factors: reprogramming protein synthesis in Cancer. Trends in Cell Biology. 2016;26:918–933. doi: 10.1016/j.tcb.2016.06.005. PubMed DOI
Hinnebusch AG. The scanning mechanism of eukaryotic translation initiation. Annual Review of Biochemistry. 2014;83:779–812. doi: 10.1146/annurev-biochem-060713-035802. PubMed DOI
Jennings MD, Kershaw CJ, Adomavicius T, Pavitt GD. Fail-safe control of translation initiation by dissociation of eIF2α phosphorylated ternary complexes. eLife. 2017;6:e24542. doi: 10.7554/eLife.24542. PubMed DOI PMC
Kapp LD, Lorsch JR. GTP-dependent recognition of the methionine moiety on initiator tRNA by translation factor eIF2. Journal of Molecular Biology. 2004;335:923–936. doi: 10.1016/j.jmb.2003.11.025. PubMed DOI
Pakos-Zebrucka K, Koryga I, Mnich K, Ljujic M, Samali A, Gorman AM. The integrated stress response. EMBO Reports. 2016;17:1374–1395. doi: 10.15252/embr.201642195. PubMed DOI PMC
Pavitt GD, Proud CG. Protein synthesis and its control in neuronal cells with a focus on vanishing white matter disease. Biochemical Society Transactions. 2009;37:1298–1310. doi: 10.1042/BST0371298. PubMed DOI