Serum Levels of IGF-1 and IGFBP-3 in Relation to Clinical and Pathobiological Aspects of Head and Neck Squamous Cell Carcinomas
Jazyk angličtina Země Řecko Médium print
Typ dokumentu srovnávací studie, časopisecké články
PubMed
28551677
DOI
10.21873/anticanres.11693
PII: 37/6/3281
Knihovny.cz E-zdroje
- Klíčová slova
- Head and neck squamous cell carcinoma, IGF-1, IGFBP-3, p16, serum tumor marker,
- MeSH
- dlaždicobuněčné karcinomy hlavy a krku MeSH
- IGFBP-3 krev MeSH
- imunohistochemie MeSH
- imunoradiometrická analýza MeSH
- inhibitor p16 cyklin-dependentní kinasy analýza MeSH
- insulinu podobný růstový faktor I analýza MeSH
- lidé středního věku MeSH
- lidé MeSH
- lokální recidiva nádoru MeSH
- nádorové biomarkery analýza krev MeSH
- nádory hlavy a krku krev chemie patologie MeSH
- prediktivní hodnota testů MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- spinocelulární karcinom krev chemie patologie MeSH
- stupeň nádoru MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- srovnávací studie MeSH
- Názvy látek
- CDKN2A protein, human MeSH Prohlížeč
- IGF1 protein, human MeSH Prohlížeč
- IGFBP-3 MeSH
- IGFBP3 protein, human MeSH Prohlížeč
- inhibitor p16 cyklin-dependentní kinasy MeSH
- insulinu podobný růstový faktor I MeSH
- nádorové biomarkery MeSH
BACKGROUND/AIM: Head and neck squamous cell carcinoma (HNSCC) includes tumors of various anatomical sites sharing multifactorial etiopathogenesis and generally dismal response to conventional treatment. The objective of this study was to determine the clinical significance of serum levels of insulin-like growth factor-1 (IGF-1) and insulin-like growth factor-binding protein-3 (IGFBP-3) in HNSCC. PATIENTS AND METHODS: A total of 46 patients, with histologically-confirmed diagnosis of HNSCC (21 oropharyngeal, 21 laryngeal, and 4 hypopharyngeal cancers) were enrolled in this study. IGF-1 and IGFBP-3 serum levels were measured by an immunoradiometric assay using commercial kits. The adjustment of serum levels at 60 years of age was performed. RESULTS: Significant differences were found in IGF-1 serum concentrations between patients with p16 positive and p16 negative HNSCC (p=0.0062), with higher IGF-1 levels in p16 positive tumors, between low-grade and high-grade cancers (p=0.0323) only in larynx, with elevated IGF-1 concentrations associated with high-grade and between recurrent and non-recurrent HNSCC (p=0.0354), with lower IGF-1 levels in recurrent tumors. CONCLUSION: The conflicting results of this study may reflect some abnormality of IGF axis regulation in HNSCC, as well as the influence of other etiological factors (e.g. smoking, HPV infection).
Citace poskytuje Crossref.org
