Atypical handedness in mesial temporal lobe epilepsy
Language English Country United States Media print-electronic
Document type Journal Article
PubMed
28575772
DOI
10.1016/j.yebeh.2017.01.034
PII: S1525-5050(16)30649-7
Knihovny.cz E-resources
- Keywords
- Age at epilepsy onset, Atypical dominance, Handedness, Left-handed, Mesial temporal lobe epilepsy, Right-handed,
- MeSH
- Child MeSH
- Adult MeSH
- Epilepsy, Temporal Lobe diagnostic imaging epidemiology physiopathology MeSH
- Functional Laterality physiology MeSH
- Hippocampus diagnostic imaging physiopathology MeSH
- Tomography, Emission-Computed, Single-Photon methods MeSH
- Infant MeSH
- Humans MeSH
- Magnetic Resonance Imaging methods MeSH
- Adolescent MeSH
- Young Adult MeSH
- Neuronal Plasticity physiology MeSH
- Child, Preschool MeSH
- Retrospective Studies MeSH
- Seizures diagnostic imaging epidemiology physiopathology MeSH
- Check Tag
- Child MeSH
- Adult MeSH
- Infant MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Male MeSH
- Child, Preschool MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
OBJECTIVE: The main aim of our study was to investigate the handedness of patients with mesial temporal lobe epilepsy (MTLE). We also sought to identify clinical variables that correlated with left-handedness in this population. METHODS: Handedness (laterality quotient) was assessed in 73 consecutive patients with MTLE associated with unilateral hippocampal sclerosis (HS) using the Edinburgh Handedness Inventory. Associations between right- and left-handedness and clinical variables were investigated. RESULTS: We found that 54 (74.0%) patients were right-handed, and 19 (26%) patients were left-handed. There were 15 (36.6%) left-handed patients with left-sided seizure onset compared to 4 (12.5%) left-handed patients with right-sided seizure onset (p=0.030). Among patients with left-sided MTLE, age at epilepsy onset was significantly correlated with handedness (8years of age [median; min-max 0.5-17] in left-handers versus 15years of age [median; min-max 3-30] in right-handers (p<0.001). CONCLUSIONS: Left-sided MTLE is associated with atypical handedness, especially when seizure onset occurs during an active period of brain development, suggesting a bi-hemispheric neuroplastic process for establishing motor dominance in patients with early-onset left-sided MTLE.
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