Cyclophilins: Less Studied Proteins with Critical Roles in Pathogenesis
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
- Klíčová slova
- protists, virulence,
- MeSH
- cyklofiliny genetika metabolismus MeSH
- fylogeneze MeSH
- houby patogenita MeSH
- imunofiliny metabolismus MeSH
- interakce hostitele a patogenu MeSH
- molekulární modely MeSH
- nemoci rostlin imunologie mikrobiologie MeSH
- oomycety patogenita MeSH
- rostliny imunologie mikrobiologie MeSH
- sekvence aminokyselin MeSH
- sekvenční seřazení MeSH
- virulence MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- cyklofiliny MeSH
- imunofiliny MeSH
Cyclophilins (EC 5.2.1.8) belong to a subgroup of proteins known as immunophilins, which also include FK506-binding proteins and parvulins. Members of the immunophilins have two main characteristic properties: (i) peptidyl-prolyl cis-trans isomerase activity and (ii) the ability to bind immunosuppressant molecules of fungal origin. Cyclophilins are some of the most conserved proteins present in eukaryotes and prokaryotes, and they have been implicated in diverse cellular processes and responses to multiple biotic and abiotic stresses. Cyclophilins have been exploited in humans and plants extensively, but they have only recently received attention in regard to phytopathogens. In Phellinus sulphurascens and species of the genus Leptosphaeria and Phytophthora, high expression of cyclophilins was found to be related to infection. Moreover, recent studies of cyclophilins in certain phytopathogens, such as Magnaporthe oryzae, Botrytis cinerea, Cryphonectria parasitica, and Puccinia triticina, demonstrated their roles as a pathogenicity factors. In addition to pathogenicity, cyclophilins have high affinity for the immunosuppressive drug cyclosporin A, which is a potent antifungal agent. Although cyclophilins are highly conserved in phytopathogens, because they have been less studied, their role remains largely unknown. In this review, we provide detailed information on the cyclophilins in several phytopathogens, including fungi and oomycetes, as well as their role in suppressing plant immunity.
Citace poskytuje Crossref.org
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