TRPV1 receptors contribute to paclitaxel-induced c-Fos expression in spinal cord dorsal horn neurons
Jazyk angličtina Země Česko Médium print
Typ dokumentu časopisecké články
PubMed
28730839
DOI
10.33549/physiolres.933613
PII: 933613
Knihovny.cz E-zdroje
- MeSH
- buňky zadních rohů míšních účinky léků metabolismus MeSH
- exprese genu MeSH
- fytogenní protinádorové látky farmakologie MeSH
- kationtové kanály TRPV antagonisté a inhibitory fyziologie MeSH
- krysa rodu Rattus MeSH
- paclitaxel farmakologie MeSH
- potkani Wistar MeSH
- protoonkogenní proteiny c-fos agonisté biosyntéza genetika MeSH
- zadní rohy míšní účinky léků metabolismus MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- fytogenní protinádorové látky MeSH
- kationtové kanály TRPV MeSH
- paclitaxel MeSH
- protoonkogenní proteiny c-fos MeSH
- Trpv1 protein, rat MeSH Prohlížeč
Transient receptor potential vanilloid type 1 (TRPV1) receptors are important in the development of different pathological chronic pain states. Here we examined the role of spinal cord TRPV1 receptors in the mechanisms leading to activation of dorsal horn neurons after paclitaxel (PAC) treatment. PAC is a widely used chemotherapeutic drug that often leads to development of painful neuropathy. Immunohistochemical analysis of c-Fos protein expression in dorsal horn neurons was used as a marker of neuronal activation. Rat spinal cord slices were processed for in vitro incubation with PAC (100 nM) and TRPV1 receptor antagonists (SB366791 and AMG9810; 10 microM). PAC treatment induced significant upregulation of c-Fos nuclear expression in superficial dorsal horn neurons that was diminished by TRPV1 receptor antagonists pre-incubation. These results further substantiated the role of spinal TRPV1 receptors in the development of paclitaxel-induced neuropathic pain and contribute to better understanding of the pathological mechanisms involved.
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