Primary signet ring stromal tumor of the testis: a study of 13 cases indicating their phenotypic and genotypic analogy to pancreatic solid pseudopapillary neoplasm
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu srovnávací studie, časopisecké články, práce podpořená grantem
PubMed
28739499
DOI
10.1016/j.humpath.2017.07.010
PII: S0046-8177(17)30260-5
Knihovny.cz E-zdroje
- Klíčová slova
- Analogue, Pancreas, Primary signet ring stromal tumor, Solid pseudopapillary neoplasm, Testis,
- MeSH
- beta-katenin analýza genetika MeSH
- biopsie MeSH
- buněčná diferenciace MeSH
- buněčný rodokmen MeSH
- dospělí MeSH
- fenotyp MeSH
- genetická predispozice k nemoci MeSH
- gonadální stromální nádory * chemie genetika imunologie patologie MeSH
- imunohistochemie MeSH
- karcinom z prstenčitých buněk * chemie genetika imunologie patologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- mutace MeSH
- mutační analýza DNA MeSH
- nádorové biomarkery analýza genetika MeSH
- nádory slinivky břišní * chemie genetika imunologie patologie MeSH
- proliferace buněk MeSH
- stupeň nádoru MeSH
- testikulární nádory * chemie genetika imunologie patologie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- srovnávací studie MeSH
- Názvy látek
- beta-katenin MeSH
- CTNNB1 protein, human MeSH Prohlížeč
- nádorové biomarkery MeSH
Primary signet ring stromal tumor of the testis (PSRSTT) is an extremely rare tumor described only twice in the literature. Pancreatic-analogue solid pseudopapillary neoplasm (SPN) of the testis is a recently reported entity with morphological overlap with PSRSTT. We reviewed our files to find all cases of PSRSTT to better characterize this entity. We studied 13 cases of PSRSTTs using histological, immunohistochemical (IHC), and molecular genetic methods and compared the results with pancreatic SPN. Grossly, the size of PSRSTTs ranged from 0.5 to 2 cm (mean 1.1). Microscopically, PSRSTTs predominantly showed a proliferation of low-grade epithelioid cells containing characteristic cytoplasmic vacuole dislodging the nucleus (signet ring cells) separated by fibrous septa into trabeculae and nests. The immunoprofile was characterized by immunoreactivity for β-catenin, cyclin D1 (nuclear positivity for both antibodies), CD10, vimentin, galectin-3, claudin 7, α-1-antitrypsin, CD56, and neuron-specific enolase and negativity for chromogranin, inhibin, calretinin, SF-1, NANOG, OCT3/4, and SALL4. In some cases, the IHC panel was restricted because of a limited amount of tissue. Molecular genetic analysis revealed mutations within exon 3 of the CTNNB1 encoding β-catenin in all analyzable cases. Based on histological similarities between pancreatic SPN and PSRSTT and their identical IHC and molecular genetic features, we assume that both neoplasms share the same pathogenesis, and thus, PSRSTT can be considered as a testicular analogue of pancreatic SPN.
Biopticka laborator s r o Plzen 30100 Czech Republic
Consultoria em Patologia Botucatu SP 18602 010 Brazil
Department of Diagnostic Pathology Kochi Red Cross Hospital Kochi 780 8562 Japan
Department of Pathology The University of Chicago Chicago 60637 USA
Department of Pathology University Hospital Centre Zagreb 100000 Croatia
Department of Pathology University of Washington Seattle 98195 USA
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