Primary signet ring stromal tumor of the testis: a study of 13 cases indicating their phenotypic and genotypic analogy to pancreatic solid pseudopapillary neoplasm
Language English Country United States Media print-electronic
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
28739499
DOI
10.1016/j.humpath.2017.07.010
PII: S0046-8177(17)30260-5
Knihovny.cz E-resources
- Keywords
- Analogue, Pancreas, Primary signet ring stromal tumor, Solid pseudopapillary neoplasm, Testis,
- MeSH
- beta Catenin analysis genetics MeSH
- Biopsy MeSH
- Cell Differentiation MeSH
- Cell Lineage MeSH
- Adult MeSH
- Phenotype MeSH
- Genetic Predisposition to Disease MeSH
- Sex Cord-Gonadal Stromal Tumors * chemistry genetics immunology pathology MeSH
- Immunohistochemistry MeSH
- Carcinoma, Signet Ring Cell * chemistry genetics immunology pathology MeSH
- Middle Aged MeSH
- Humans MeSH
- Young Adult MeSH
- Mutation MeSH
- DNA Mutational Analysis MeSH
- Biomarkers, Tumor analysis genetics MeSH
- Pancreatic Neoplasms * chemistry genetics immunology pathology MeSH
- Cell Proliferation MeSH
- Neoplasm Grading MeSH
- Testicular Neoplasms * chemistry genetics immunology pathology MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Young Adult MeSH
- Male MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Names of Substances
- beta Catenin MeSH
- CTNNB1 protein, human MeSH Browser
- Biomarkers, Tumor MeSH
Primary signet ring stromal tumor of the testis (PSRSTT) is an extremely rare tumor described only twice in the literature. Pancreatic-analogue solid pseudopapillary neoplasm (SPN) of the testis is a recently reported entity with morphological overlap with PSRSTT. We reviewed our files to find all cases of PSRSTT to better characterize this entity. We studied 13 cases of PSRSTTs using histological, immunohistochemical (IHC), and molecular genetic methods and compared the results with pancreatic SPN. Grossly, the size of PSRSTTs ranged from 0.5 to 2 cm (mean 1.1). Microscopically, PSRSTTs predominantly showed a proliferation of low-grade epithelioid cells containing characteristic cytoplasmic vacuole dislodging the nucleus (signet ring cells) separated by fibrous septa into trabeculae and nests. The immunoprofile was characterized by immunoreactivity for β-catenin, cyclin D1 (nuclear positivity for both antibodies), CD10, vimentin, galectin-3, claudin 7, α-1-antitrypsin, CD56, and neuron-specific enolase and negativity for chromogranin, inhibin, calretinin, SF-1, NANOG, OCT3/4, and SALL4. In some cases, the IHC panel was restricted because of a limited amount of tissue. Molecular genetic analysis revealed mutations within exon 3 of the CTNNB1 encoding β-catenin in all analyzable cases. Based on histological similarities between pancreatic SPN and PSRSTT and their identical IHC and molecular genetic features, we assume that both neoplasms share the same pathogenesis, and thus, PSRSTT can be considered as a testicular analogue of pancreatic SPN.
Biopticka laborator s r o Plzen 30100 Czech Republic
Consultoria em Patologia Botucatu SP 18602 010 Brazil
Department of Diagnostic Pathology Kochi Red Cross Hospital Kochi 780 8562 Japan
Department of Pathology The University of Chicago Chicago 60637 USA
Department of Pathology University Hospital Centre Zagreb 100000 Croatia
Department of Pathology University of Washington Seattle 98195 USA
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