In many developing countries, jaundice is the common symptom of hepatic diseases which are a major cause of mortality. The use of natural product-based therapies is very popular for such hepatic disorders. A great number of medicinal plants have been utilized for this purpose and some facilitated the discovery of active compounds which helped the development of new synthetic drugs against jaundice. However, more epidemiological studies and clinical trials are required for the practical implementation of the plant pharmacotherapy of jaundice. The focus of this second part of our review is on several of the most prominent plants used against jaundice identified in the analysis performed in the first part of the review viz. Andrographis paniculata (Burm.f.) Nees, Silybum marianum (L.) Gaertn., Terminalia chebula Retz., Glycyrrhiza glabra L. and some species of genus Phyllanthus. Furthermore, we discuss their physiological effects, biologically active ingredients, and the potential mechanisms of action. Some of the most important active ingredients were silybin (also recommended by German commission), phyllanthin and andrographolide, whose action leads to bilirubin reduction and normalization of the levels of relevant serum enzymes indicative for the pathophysiological status of the liver.

Applied Biotechnology Research Center Baqiyatallah University of Medical SciencesTehran Iran

Department of Pharmaceutical Botany Iuliu Haţieganu University of Medicine and PharmacyCluj Napoca Romania

Department of Pharmaceutical Sciences Faculty of Technology Kumaun UniversityNainital India

Department of Pharmacognosy University of ViennaVienna Austria

Department of Public Health Xi'an Jiaotong Liverpool UniversitySuzhou China

Department of Vascular Biology and Thrombosis Research Centre for Physiology and Pharmacology Medical University of ViennaVienna Austria

Division BIOCEV Institute of Molecular Genetics Academy of Sciences of the Czech RepublicPrague Czechia

ICHAT and Institute for Life Sciences University of Agricultural Sciences and Veterinary MedicineCluj Napoca Romania

Institute of Genetics and Animal Breeding of the Polish Academy of SciencesJastrzebiec Poland

School of Medical Sciences Universiti Sains MalaysiaKota Bharu Malaysia

Erratum v

Front Pharmacol. 2017 Oct 06;8:690. doi: 10.3389/fphar.2017.00690. PubMed

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Agarwal K., Dhir H., Sharma A., Talukder G. (1992). The efficacy of two species of

Akbarsha M. A., Murugaian P. (2000). Aspects of the male reproductive toxicity/male antifertility property of andrographolide in albino rats: effect on the testis and the cauda epididymidal spermatozoa. PubMed DOI

Alcaraz M. J., Jiménez M. J. (1988). Flavonoids as anti-inflammatory agents.

Al-Qarawi A. A., Abdel-Rahman H. A., El-Mougy S. A. (2001). Hepatoprotective activity of licorice in rat liver injury models. DOI

Anand K. K., Singh B., Saxena A. K., Chandan B. K., Gupta V. N. (1994). Hepatoprotective studies of a fraction from the fruits of DOI

Angulo P., Patel T., Jorgensen R. A., Therneau T. M., Lindor K. D. (2000). Silymarin in the treatment of patients with primary biliary cirrhosis with a suboptimal response to ursodeoxycholic acid. PubMed DOI

Arase Y., Ikeda K., Murashima N., Chayama K., Tsubota A., Koida I., et al. (1997). The long term efficacy of glycyrrhizin in chronic hepatitis C patients. PubMed DOI

Arseculeratne S. N., Gunatilaka A. A. L., Panabokke R. G. (1985). Studies on medicinal plants of Sri Lanka. Part 14: toxicity of some traditional medicinal herbs. PubMed DOI

Asl M. N., Hosseinzadeh H. (2008). Review of pharmacological effects of Glycyrrhiza sp. and its bioactive compounds. PubMed DOI PMC

Bachmann T. L., Ghia F., Torssell K. B. G. (1993). Lignans and lactones from DOI

Bagalkotkar G., Sagineedu S. R., Saad M. S., Stanslas J. (2006). Phytochemicals from PubMed DOI

Barzaghi N., Crema F., Gatti G., Pifferi G., Perucca E. (1990). Pharmacokinetic studies on IdB 1016, a silybin-phosphatidylcholine complex, in healthy human subjects. PubMed DOI

Beretz A., Anton R., Stoclet J. C. (1978). Flavonoid compounds are potent inhibitors of cyclic AMP phosphodiesterase. PubMed DOI

Blumenthal M., Goldberg A., Brinkmann J. (2000).

Bunout D., Hirsch S., Petermann M., De La Maza M. P., Silva G., Kelly M., et al. (1992). Controlled study of the effect of silymarin on alcoholic liver disease. PubMed

Cai Y., Xu Y., Chan H. F., Fang X., He C., Chen M. (2016). Glycyrrhetinic acid mediated drug delivery carriers for hepatocellular carcinoma therapy. PubMed DOI

Calabrese C., Berman S. H., Babish J. G., Ma X., Shinto L., Dorr M., et al. (2000). A phase I trial of andrographolide in HIV positive patients and normal volunteers. PubMed DOI

Calixto J. B., Santos A. R. S., Filho V. C., Yunes R. A. (1998). A review of the plants of the genus PubMed DOI

Campos A. H., Schor N. (1999). PubMed DOI

Chander R., Srivastava V., Tandon And J. S., Kapoor N. K. (1995). Antihepatotoxic activity of diterpenes of DOI

Chatterjee A., Pakrashi S. C. (1991).

Choi M.-K., Kim H.-G., Han J.-M., Lee J.-S., Lee J. S., Chung S. H., et al. (2015). Hepatoprotective effect of PubMed DOI PMC

Chopra R. N., Nayar S. L., Chopra I. C., Asolkar L. V., Kakkar K. K., Chakre O. J. (1956).

Choudhury B. R., Poddar M. K. (1984). Andrographolide and kalmegh ( PubMed

Chturvedi G. N., Tomar G. S., Tiwari S. K., Singh K. P. (1983). Clinical studies on Kalmegh ( PubMed PMC

Cruz T., Galvez J., Ocete M. A., Crespo M. E., Sanchez de Medina L.-H. F., Zarzuelo A. (1998). Oral administration of rutoside can ameliorate inflammatory bowel disease in rats. PubMed DOI

Cruz-Vega D., Verde-Star M. J., Salinas-Gonzalez N. R., Rosales-Hernandez B., Estrada-Garcia I., Mendez-Aragon P., et al. (2009). Review of pharmacological effects of PubMed

Dafni A., Yaniv Z., Palevitch D. (1984). Ethnobotanical survey of medicinal plants in northern Israel. PubMed DOI

Dastagir G., Rizvi M. A. (2016). PubMed

Deng W. L., Nie R. J., Liu J. Y. (1982). Comparison of pharmacological effect of four andrographolides.

Dhar M. L., Dhar M. M., Dhawan B. N., Mehrotra B. N., Roy C. (1968). Screening of Indian plants for biological activity: Part 1. PubMed

Dhir H., Roy A. K., Sharma A., Talukder G. (1990). Protection afforded by aqueous extracts of Phyllanthus species against cytotoxicity induced by lead and aluminium salts. DOI

Dias M. A., Campos A. H., Cechinel Filho V., Yunes R. A. C. J. (1995). Analysis of the mechanisms underlying the contractile response induced by the hydroalcoholic extract of PubMed DOI

Dixit S. P., Achar M. P., Thabrew M. R. (1982).

Duarte J., Perez-Vizcaino F., Zarzuelo A., Jimenez J., Tamargo J. (1993). Vasodilator effects of quercetin in isolated rat vascular smooth muscle. PubMed DOI

Eerdunbayaer, Orabi M. A. A., Aoyama H., Kuroda T., Hatano T. (2014). Structures of new phenolics isolated from licorice, and the effectiveness of licorice phenolics on vancomycin-resistant Enterococci. PubMed DOI PMC

Epstein M. T., Espiner E. A., Donald R. A., Hughes H. (1977). Effect of eating liquorice on the renin-angiotensin aldosterone axis in normal subjects. PubMed DOI PMC

Evans W. C. (2009).

Feher J., Deák G., Muzes G. (1989). Hepatoprotective activity of silymarin (Legalon) therapy in patients with chronic liver disease. PubMed

Ferenci P., Dragosics B., Dittrich H., Frank H., Benda L., Lochs H., et al. (1989). Randomized controlled trial of silymarin treatment in patients with cirrhosis of the liver. PubMed DOI

Filho V. C., Santos A. R. S., Campos R. O. P., Miguel O. G., Yunes R. A., Ferrari F., et al. (1996). Chemical and pharmacological studies of PubMed DOI

Finney R. S. H., Somers G. F. (1958). The antiinflammatory activity of glycyrrhetinic acid and derivatives. PubMed DOI

Fleming T. (1998).

Flora K., Hahn M., Rosen H., Benner K. (1998). Milk thistle ( PubMed DOI

Flora K. D., Rosen H. R., Benner K. G. (1996). The use of naturopathic remedies for chronic liver disease. PubMed

Foo L. Y. (1995). Amariinic acid and related ellagitannins from Phyllanthus amarus. DOI

Foo L. Y., Wong H. (1992). Phyllanthusiin D, an unusual hydrolysable tannin from DOI

Foster S. (1991).

Fu B., Li S., Yu X., Yang P., Yu G., Feng R., et al. (2010). Chinese ecosystem research network: progress and perspectives. DOI

Fujita T., Sezik E., Tabata M., Yesilada E., Honda G., Takeda Y., et al. (1995). Traditional medicine in Turkey VII. Folk medicine in middle and west Black Sea regions. DOI

Fukai T., Tantai L., Nomura T. (1996). Isoprenoid-substituted flavonoids from DOI

Gálvez J., Cruz T., Crespo E., Ocete M. A., Lorente M. D., de Medina F. S., et al. (1997). Rutoside as mucosal protective in acetic acid-induced rat colitis. PubMed DOI

Gálvez J., Sánchez de Medina F., Jiménez J., Torres M. I., Fernández M. I., Núñez M. C., et al. (1995). Effect of quercitrin on lactose-induced chronic diarrhoea in rats. PubMed DOI

Gazak R., Walterova D., Kren V. (2007). Silybin and silymarin–new and emerging applications in medicine. PubMed DOI

Girach R. D., Aminuddin Siddiqui P. A., Khan S. A. (1994). Traditional plant remedies among the Kondh of district Dhenkanal (Orissa). DOI

Greive M. (1981).

Gulati R. K., Agarwal S., Agrawal S. S. (1995). Hepatoprotective studies on PubMed

Gupta S., Choudhry M. A., Yadava J. N. S., Srivastava V., Tandon J. S. (1990). Antidiarrhoeal activity of diterpenes of DOI

Handa S. S., Sharma A. (1990). Hepatoprotective activity of andrographolide from PubMed

Harnisch G., Stolze H. (1983). “Silybum marianum: mariendistel,” in

Harrison P. M. (1977). Ferritin: an iron-storage molecule. PubMed

Hidaka I., Hino K., Korenaga M., Gondo T., Nishina S., Ando M., et al. (2007). Stronger Neo-Minophagen CTM, a glycyrrhizin-containing preparation, protects liver against carbon tetrachloride-induced oxidative stress in transgenic mice expressing the hepatitis C virus polyprotein. PubMed DOI

Hino K., Sainokami S., Shimoda K., Iino S., Wang Y., Okamoto H., et al. (1994). Genotypes and titers of hepatitis C virus for predicting response to interferon in patients with chronic hepatitis C. PubMed DOI

Hiramatsu N., Hayashi N., Katayama K., Mochizuki K., Kawanishi Y., Kasahara A., et al. (1994). Immunohistochemical detection of Fas antigen in liver tissue of patients with chronic hepatitis C. PubMed DOI

Hobbs C. (1987).

Huo H. Z., Wang B., Liang Y. K., Bao Y. Y., Gu Y. (2011). Hepatoprotective and antioxidant effects of licorice extract against CCl4-induced oxidative damage in rats. PubMed DOI PMC

Hussain R. A., Dickey J. K., Rosser M. P., Matson J. A., Kozlowski M. R., Brittain R. J., et al. (1995). A novel class of non-peptidic endothelin antagonists isolated from the medicinal herb DOI

Ikeda K., Arase Y., Kobayashi M., Saitoh S., Someya T., Hosaka T., et al. (2006). A long-term glycyrrhizin injection therapy reduces hepatocellular carcinogenesis rate in patients with interferon-resistant active chronic hepatitis C: a cohort study of 1249 patients. PubMed DOI

Ikeda K., Saitoh S., Koida I., Arase Y., Tsubota A., Chayama K., et al. (1993). A multivariate analysis of risk factors for hepatocellular carcinogenesis: a prospective observation of 795 patients with viral and alcoholic cirrhosis. PubMed DOI

Iruretagoyena M. I., Tobar J. A., González P. A., Sepúlveda S. E., Figueroa C. A., Burgos R. A., et al. (2004). Andrographolide interferes with T cell activation and reduces experimental autoimmune encephalomyelitis in the mouse. PubMed DOI

Ishikawa S., Saito T. (1980). The effect of glycyrrhetinic acid on the action of aldosterone in stimulating sodium transport in frog skin. PubMed DOI

Ishimaru K., Yoshimatsu K., Yamakawa T., Kamada H., Shimomura K. (1992). Phenolic constituents in tissue cultures of DOI

Jarukamjorn K., Don-in K., Makejaruskul C., Laha T., Daodee S., Pearaksa P., et al. (2006). Impact of PubMed DOI

Jeong H. G., You H. J., Park S. J., Moon A. R., Chung Y. C., Kang S. K., et al. (2002). Hepatoprotective effects of 18β-glycyrrhetinic acid on carbon tetrachloride-induced liver injury: inhibition of cytochrome P450 2E1 expression. PubMed DOI

Juang L., Sheu S., Lin T. (2004). Determination of hydrolyzable tannins in the fruit of PubMed DOI

Kapil A., Koul I. B., Banerjee S. K., Gupta B. D. (1993). Antihepatotoxic effects of major diterpenoid constituents of PubMed DOI

Ketterer B. (1988). Protective role of glutathione and glutathione transferases in mutagenesis and carcinogenesis. PubMed DOI

Khatoon S., Rai V., Rawat A. K. S., Mehrotra S. (2006). Comparative pharmacognostic studies of three Phyllanthus species. PubMed DOI

Kimura M., Watanabe H., Abo T. (1992). Selective activation of extrathymic T cells in the liver by glycyrrhizin. PubMed DOI

Kitagawa I., Chen W. Z., Hori K., Harada E., Yasuda N., Yoshikawa M., et al. (1994). Chemical studies of Chinese licorice-roots. I. elucidation of five new flavonoid constituents from the roots of PubMed DOI

Kokate C. K., Purohit A. P., Gokhale S. B. (2003).

Kumar R. A., Sridevi K., Kumar N. V., Nanduri S., Rajagopal S. (2004). Anticancer and immunostimulatory compounds from PubMed DOI

Kusirisin W., Srichairatanakool S., Lerttrakarnnon P., Lailerd N., Suttajit M., Jaikang C., et al. (2009). Antioxidative activity, polyphenolic content and anti-glycation effect of some Thai medicinal plants traditionally used in diabetic patients. PubMed DOI

Lau G. K., Tsiang M., Hou J., Yuen S., Carman W. F., Zhang L., et al. (2000). Combination therapy with lamivudine and famciclovir for chronic hepatitis B–infected Chinese patients: a viral dynamics study. PubMed DOI

Lee C. D., Ott M., Thyagarajan S. P., Shafritz D. A., Burk R. D., Gupta S. (1996). Phyllanthus amarus down-regulates hepatitis B virus mRNA transcription and replication. PubMed DOI

Lee H.-S., Won N. H., Kim K. H., Lee H., Jun W., Lee K.-W. (2005). Antioxidant effects of aqueous extract of PubMed DOI

Lee J. R., Park S. J., Lee H.-S., Jee S. Y., Seo J., Kwon Y. K., et al. (2009). Hepatoprotective activity of licorice water extract against cadmium-induced toxicity in rats. PubMed DOI PMC

Lee S., Hyun P., Kim S., Kim K., Lee S., Kim B., et al. (2005). Suppression of the onset and progression of collagen-induced arthritis by chebulagic acid screened from a natural product library. PubMed DOI

Leng-Peschlow E. (1994). Alcohol-related liver diseases-use of Legalon

Li Z., Li Q., Jiang X., Zhang K., Guan R. (2014). Isolation and preparation of gallic acid from PubMed

Lin C. N., Tome W. P. (1988). Antihepatotoxic principles of Sambucus formosana. PubMed DOI

Lin G., Nnane I. P., Cheng T.-Y. (1999). The effects of pretreatment with glycyrrhizin and glycyrrhetinic acid on the retrorsine-induced hepatotoxicity in rats. PubMed DOI

Lindahl M., Tagesson C. (1993). Selective inhibition of group II phospholipase A2 by quercetin. PubMed DOI

Loguercio C., Festi D. (2011). Silybin and the liver: from basic research to clinical practice. PubMed DOI PMC

Luper S. (1998). A review of plants used in the treatment of liver disease: part 1. PubMed

Mabberley D. J. (2008).

Magliulo E., Gagliardi B., Fiori G. P. (1978). Results of a double blind study on the effect of silymarin in the treatment of acute viral hepatitis, carried out at two medical centres (author’s transl). PubMed

Mao X., Wu L.-F., Guo H.-L., Chen W.-J., Cui Y.-P., Qi Q., et al. (2016). The genus Phyllanthus: an ethnopharmacological, phytochemical, and pharmacological review. PubMed PMC

Meister A. (1994). Glutathione, ascorbate, and cellular protection. PubMed

Meyer H. S., Eldredge J. D., Hogan R. (1999). Herbal medicines. The complete german commission e monographs: therapeutic guide to herbal medicines. DOI

Mhaskar K. S., Blatter E., Caius J. F. (2000).

Miadonna A., Tedeschi A., Leggieri E., Lorini M., Froldi M., Zanussi C. (1987). Effects of silybin on histamine release from human basophil leucocytes. PubMed DOI PMC

Mita E., Hayashi N., Iio S., Takehara T., Hijioka T., Kasahara A., et al. (1994). Role of fas ligand in apoptosis induced by hepatitis C virus infection. PubMed DOI

Miyakawa Y., Iino S. (2001). Toward prevention of hepatocellular carcinoma developing in chronic hepatitis C. PubMed DOI

Morales M. A., Lozoya X. (1994). Calcium-antagonist effects of quercetin on aortic smooth muscle. PubMed DOI

Morazzoni P., Bombardelli E. (1995).

Morton J. F. (1981).

Mourelle M., Muriel P., Favari L., Franco T. (1989). Prevention of CCl4-induced liver cirrhosis by silymarin. PubMed DOI

Naik A. D., Juvekar A. R. (2003). Effects of alkaloidal extract of PubMed

Nakamura T., Fujii T., Ichihara A. (1985). Enzyme leakage due to change of membrane permeability of primary cultured rat hepatocytes treated with various hepatotoxins and its prevention by glycyrrhizin. PubMed DOI

Nanduri S., Nyavanandi V. K., Thunuguntla S. S. R., Kasu S., Pallerla M. K., Ram P. S., et al. (2004). Synthesis and structure-activity relationships of andrographolide analogues as novel cytotoxic agents. PubMed DOI

Nomura T., Fukai T., Akiyama T. (2002). Chemistry of phenolic compounds of licorice ( DOI

Nose M., Ito M., Kamimura K., Shimizu M., Ogihara Y. (1994). A comparison of the antihepatotoxic activity between glycyrrhizin and glycyrrhetinic acid. PubMed DOI

Ody P. (2000).

Ogata T., Higuchi H., Mochida S., Matsumoto H., Kato A., Endo T., et al. (1992). HIV-1 reverse transcriptase inhibitor from PubMed DOI

Ohno H., Miyoshi S., Araho D., Kanamoto T., Terakubo S., Nakashima H., et al. (2014). Efficient utilization of licorice root by alkaline extraction. PubMed

Ohuchi K., Tsurufuji A. (1982). A study of the anti-inflammatory mechanism of glycyrrhizin.

Oliver-Bever B. (1983). Medicinal plants in tropical west africa III. Anti-infection therapy with higher plants. PubMed DOI

Owoyele B. V., Olaleye S. B., Oke J. M., Elegbe R. A. (2001). Anti-Inflammatory and analgesic activities of leaf extracts of

Padmalatha K., Jayaram K., Raju N. L., Prasad M. N. V., Arora R. (2009). Ethnopharmacological and biotechnological significance of DOI

Panunto W., Jaijoy K., Lerdvuthisopon N., Lertprasertsuke N., Jiruntanat N., Soonthornchareonnon N., et al. (2010). Acute and chronic toxicity studies of the water extract from dried fruits of Terminalia chebula Rezt. in rats.

Parés A., Planas R., Torres M., Caballería J., Viver J. M., Acero D., et al. (1998). Effects of silymarin in alcoholic patients with cirrhosis of the liver: results of a controlled, double-blind, randomized and multicenter trial. PubMed DOI

Pathak D., Pathak K., Singla A. K. (1991). Flavonoids as medicinal agents-recent advances.

Perry L. M., Metzger J. (1980).

Pettit G. R., Cragg G. M., Gust D., Brown P., Schmidt J. M. (1982a). The structures of phyllanthostatin 1 and phyllanthoside from the Central American tree

Pettit G. R., Cragg G. M., Herald D. L., Schmidt J. M., Lohavanijaya P. (1982b). Isolation and structure of combretastatin. DOI

Piva R., Penolazzi L., Borgatti M., Lampronti I., Lambertini E., Torreggiani E., et al. (2009). Apoptosis of human primary osteoclasts treated with molecules targeting nuclear factor-κB. PubMed DOI

Polya G. M., Wang B. H., Foo L. Y. (1995). Inhibition of signal-regulated protein kinases by plant-derived hydrolysable tannins. PubMed DOI

Pradhan S. C., Girish C. (2006). Hepatoprotective herbal drug, silymarin from experimental pharmacology to clinical medicine. PubMed

Prakash A., Satyan K. S., Wahi S. P., Singh R. P. (1995). Comparative hepatoprotective activity of three DOI

Pramyothin P., Udomuksorn W., Poungshompoo S., Chaichantipyuth C. (1994). Hepatoprotective effect of

Puri A., Saxena R., Saxena R. P., Saxena K. C., Srivastava V., Tandon J. S. (1993). Immunostimulant agents from PubMed DOI

Qian-Cutrone J., Huang S., Trimble J., Li H., Lin P. F., Alam M., et al. (1996). Niruriside, a new HIV REV/RRE binding inhibitor from PubMed DOI

Rajurkar N. S., Pardeshi B. M. (1997). Analysis of some herbal plants from India used in the control of diabetes mellitus by NAA and AAS techniques. PubMed DOI

Ramellini G., Meldolesi J. (1974). Stabilization of isolated rat liver plasma membranes by treatment in vitro with silymarin. PubMed

Raphael T. J., Kuttan G. (2003). Effect of naturally occurring triterpenoids glycyrrhizic acid, ursolic acid, oleanolic acid and nomilin on the immune system. PubMed DOI

Row L. R., Srinivasulu C., Smith M., Rao G. S. R. S. (1966). Crystalline constituents of euphorbiaceae-V. DOI

Rush G. F., Gorski J. R., Ripple M. G., Sowinski J., Bugelski P., Hewitt W. R. (1985). Organic hydroperoxide-induced lipid peroxidation and cell death in isolated hepatocytes. PubMed DOI

Sabouri Ghannad M., Mohammadi A., Safiallahy S., Faradmal J., Azizi M., Ahmadvand Z. (2014). The effect of aqueous extract of PubMed DOI PMC

Salmi H., Sarna S. (1982). Effect of silymarin on chemical, functional, and morphological alterations of the liver: a double-blind controlled study. PubMed DOI

Sanchez de Medina F., Vera B., Galvez J., Zarzuelo A. (2002). Effect of quercitrin on the early stages of hapten induced colonic inflammation in the rat. PubMed DOI

Santos A. R., Filho V. C., Niero R., Viana A. M., Moreno F. N., Campos M. M., et al. (1994). Analgesic effects of callus culture extracts from selected species of PubMed DOI

Saraswat B., Visen P. K. S., Patnaik G. K., Dhawan B. N. (1995). Effect of andrographolide against galactosamine-induced hepatotoxicity.

Sarkar R., Hazra B., Mandal N. (2012). Reducing power and iron chelating property of PubMed DOI PMC

Satomi Y., Nishino H., Shibata S. (2005). Glycyrrhetinic acid and related compounds induce G1 arrest and apoptosis in human hepatocellular carcinoma HepG2. PubMed

Schuppan D., Jia J., Brinkhaus B., Hahn E. G. (1999). Herbal products for liver diseases: a therapeutic challenge for the new millennium. PubMed DOI

Sharma A., Rathore H. S. (2010). Prevention of acetaminophen induced hepatorenal toxicity in mice with fruits of

Sharma A., Singh R. T., Sehgal V., Handa S. S. (1991). Antihepatotoxic activity of some plants used in herbal formulations. DOI

Shebl R. I., Amin M. A., Emad-Eldin A., Bin Dajem S. M., Mostafa A. S., Ibrahim E. H., et al. (2012). Antiviral activity of liquorice powder extract against varicella zoster virus isolated from Egyptian patients. PubMed

Shen Y.-C., Chen C.-F., Chiou W.-F. (2002). Andrographolide prevents oxygen radical production by human neutrophils: possible mechanism(s) involved in its anti-inflammatory effect. PubMed DOI PMC

Shibata S. (2000). A drug over the millennia: pharmacognosy, chemistry, and pharmacology of licorice. PubMed DOI

Shiki Y., Shirai K., Saito Y., Yoshida S. H. O., Mori Y., Wakashin M. (1992). Effect of glycyrrhizin on lysis of hepatocyte membranes induced by anti-liver cell membrane antibody. PubMed DOI

Shimizu M., Horie S., Terashima S., Ueno H., Hayashi T., Arisawa M., et al. (1989). Studies on aldose reductase inhibitors from natural products. II. Active components of a Paraguayan crude drug “Para-parai mi,” PubMed DOI

Shisheva A., Shechter Y. (1992). Quercetin selectively inhibits insulin receptor function in vitro and the bioresponses of insulin and insulinomimetic agents in rat adipocytes. PubMed

Šimanek V., Kren V., Ulrichová J., Vicar J., Cvak L. (2000). Silymarin: what is in the name? An appeal for a change of editorial policy. PubMed DOI

Singh R. P., Banerjee S., Rao A. R. (2001). Modulatory influence of PubMed DOI

Srividya N., Periwal S. (1995). Diuretic, hypotensive and hypoglycaemic effect of PubMed DOI

Suolinna E. M., Lang D. R., Racker E. (1974). Quercetin, an artificial regulator of the high aerobic glycolysis of tumor cells. PubMed

Suzuki H. (1983). Effects of glycyrrhizin on biochemical tests in patients with chronic hepatitis. DOI

Suzuki H., Ohta Y., Takino T., Fujisawa K., Hirayama C., Shimizu N., et al. (1977). The therapeutic effects of stronger neo minophagen C for chronic hepatitis.

Syamasundar K. V., Singh B., Thakur R. S., Husain A., Kiso Y., Hikino H. (1985). Antihepatotoxic principles of PubMed

Takahara T., Watanabe A., Shiraki K. (1994). Effects of glycyrrhizin on hepatitis B surface antigen: a biochemical and morphological study. PubMed DOI

Tanaka N., Yamamura Y., Santa T., Kotaki H., Uchino K., Sawada Y., et al. (1993). Pharmacokinetic profiles of glycyrrhizin in patients with chronic hepatitis. PubMed DOI

Tănăsescu C., Petrea S., Băldescu R., Macarie E., Chiriloiu C., Purice S. (1987). Use of the Romanian product Silimarina in the treatment of chronic liver diseases. PubMed DOI

Tandon A., Tandon B. N., Bhujwala R. A. (2001). Treatment of subacute hepatitis with lamivudine and intravenous glycyrrhizin: a pilot study. PubMed DOI

Tandon A., Tandon B. N., Bhujwala R. A. (2002). Clinical spectrum of acute sporadic hepatitis E and possible benefit of glycyrrhizin therapy. PubMed DOI

Tasaduq S. A., Singh K., Sethi S., Sharma S. C., Bedi K. L., Singh J., et al. (2003). Hepatocurative and antioxidant profile of HP-1, a polyherbal phytomedicine. PubMed DOI

Tasduq S. A., Singh K., Satti N. K., Gupta D. K., Suri K. A., Johri R. K. (2006). PubMed DOI

Thai Pharmacopoeia Committee (1995). Thai herbal pharmacopoeia.

Thyagarajan S. P., Thirunalasundari T., Subramanian S., Venkateswaran P. S., Blumberg B. S. (1988). Effect of phyllanthus amarus on chronic carriers of hepatitis b virus. PubMed DOI

Trivedi N., Rawal U. M. (2000). Hepatoprotective and toxicological evaluation of

Uesato S., Kitagawa Y., Kamishimoto M., Kumagai A., Hori H., Nagasawa H. (2001). Inhibition of green tea catechins against the growth of cancerous human colon and hepatic epithelial cells. PubMed DOI

Ullah M., Khan M. U., Mahmood A., Malik R. N., Hussain M., Wazir S. M., et al. (2013). An ethnobotanical survey of indigenous medicinal plants in Wana district south Waziristan agency. PubMed DOI

Ulmann A., Menard J., Corvol P. (1975). Binding of glycyrrhetinic acid to kidney mineralocorticoid and glucocorticoid receptors. PubMed DOI

Umarani D., Devaki T., Govindaraju P., Shanmugasundaram K. R. (1985). Ethanol induced metabolic alterations and the effect of PubMed PMC

Unander D. W., Blumberg B. S. (1991). In vitro activity of DOI

Unander D. W., Webster G. L., Blumberg B. S. (1990). Records of usage or assays in PubMed DOI

Unander D. W., Webster G. L., Blumberg B. S. (1991). Uses and bioassays in PubMed DOI

Unander D. W., Webster G. L., Blumberg B. S. (1992). Usage and bioassays in PubMed DOI

Unander D. W., Webster G. L., Blumberg B. S. (1995). Usage and bioassays in PubMed DOI

Utsumi K. (1984). Action of glycyrrhizin on biomembrane [in Japanese].

van Rossum T. G., Vulto A. G., Hop W. C., Brouwer J. T., Niesters H. G., Schalm S. W. (1999). Intravenous glycyrrhizin for the treatment of chronic hepatitis C: a double-blind, randomized, placebo-controlled phase I/II trial. PubMed DOI

van Rossum T. G., Vulto A. G., Hop W. C., Schalm S. W. (2001). Glycyrrhizin-induced reduction of ALT in European patients with chronic hepatitis C. PubMed DOI

Varshney I. P., Jain D. C., Srivastava H. C. (1983). Study of saponins from DOI

Veldt B. J., Hansen B. E., Ikeda K., Verhey E., Suzuki H., Schalm S. W. (2006). Long-term clinical outcome and effect of glycyrrhizin in 1093 chronic hepatitis C patients with non-response or relapse to interferon. PubMed DOI

Venkateswaran P. S., Millman I., Blumberg B. S. (1987). Effects of an extract from PubMed DOI PMC

Visen P. K. S., Shukia B., Patnaik G. K., Dhawan B. N. (1993). Andrographolide protects rat hepatocytes against paracetamol-induced damage. PubMed DOI

Wagner H., Diesel P., Seitz M. (1974). The chemistry and analysis of silymarin from PubMed

Wakamatsu T., Nakahashi Y., Hachimine D., Seki T., Okazaki K. (2007). The combination of glycyrrhizin and lamivudine can reverse the cisplatin resistance in hepatocellular carcinoma cells through inhibition of multidrug resistance-associated proteins. PubMed DOI

Wang B. E. (2000). Treatment of chronic liver diseases with traditional Chinese medicine. PubMed DOI

Wang L., Yang R., Yuan B., Liu Y., Liu C. (2015). The antiviral and antimicrobial activities of licorice, a widely-used Chinese herb. PubMed DOI PMC

Wang M., Cheng H., Li Y., Meng L., Zhao G., Mai K. (1995). Herbs of the genus PubMed

Wang Y., Kong L., Chen Y. (2005). Behavioural and biochemical effects of fractions prepared from Banxia houpu decoction in depression models in mice. PubMed DOI

Wang Z., Okamoto M., Kurosaki Y., Nakayama T., Kimura T. (1996). Pharmacokinetics of glycyrrhizin in rats with D-galactosamine-induced hepatic disease. PubMed DOI

Watari N. (1973). An electronmicroscopic study of the effects of glycyrrhizin on experimentally injured liver.

Wellington K., Jarvis B. (2001). Silymarin: a review of its clinical properties in the management of hepatic disorders. PubMed DOI

WHO (1999).

Williamson E. M. (2003). “Liquorice,” in

Wong W., Wu P., Yuen M., Cheng C., Yew W., Wong P., et al. (2000). Antituberculosis drug-related liver dysfunction in chronic hepatitis B infection. PubMed DOI

Xu H. (1986).

Yamamoto S., Maekawa Y., Imamura M., Hisajima T. (1958). Treatment of hepatitis with the antiallergic drug, Stronger Neo-Minophagen C.

Yamamura Y., Tanaka N., Santa T., Kotaki H., Aikawa T., Uchino K., et al. (1995). The relationship between pharmacokinetic behaviour of glycyrrhizin and hepatic function in patients with acute hepatitis and liver cirrhosis. PubMed DOI

Yang R., Yuan B.-C., Ma Y.-S., Zhou S., Liu Y. (2016). The anti-inflammatory activity of licorice, a widely used Chinese Herb. PubMed DOI PMC

Yarnell E. (1997). Botanical medicine for cystitis. DOI

Yeasmin T., Akhter Q. S., Tasnim M., Jahan S. (2016). Hepatoprotective effect of

Yeh S. F., Hong C. Y., Huang Y. L., Liu T. Y., Choo K. B., Chou C. K. (1993). Effect of an extract from PubMed DOI

Yoshikawa M., Matsui Y., Kawamoto H., Umemoto N., Oku K., Koizumi M., et al. (1997). Effects of glycyrrhizin on immune-mediated cytotoxicity. PubMed DOI

Yu J.-Y., Ha J. Y., Kim K.-M., Jung Y.-S., Jung J.-C., Oh S. (2015). Anti-Inflammatory activities of licorice extract and its active compounds, glycyrrhizic acid, liquiritin and liquiritigenin, in BV2 cells and mice liver. PubMed DOI PMC

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