In many developing countries, jaundice is the common symptom of hepatic diseases which are a major cause of mortality. The use of natural product-based therapies is very popular for such hepatic disorders. A great number of medicinal plants have been utilized for this purpose and some facilitated the discovery of active compounds which helped the development of new synthetic drugs against jaundice. However, more epidemiological studies and clinical trials are required for the practical implementation of the plant pharmacotherapy of jaundice. The focus of this second part of our review is on several of the most prominent plants used against jaundice identified in the analysis performed in the first part of the review viz. Andrographis paniculata (Burm.f.) Nees, Silybum marianum (L.) Gaertn., Terminalia chebula Retz., Glycyrrhiza glabra L. and some species of genus Phyllanthus. Furthermore, we discuss their physiological effects, biologically active ingredients, and the potential mechanisms of action. Some of the most important active ingredients were silybin (also recommended by German commission), phyllanthin and andrographolide, whose action leads to bilirubin reduction and normalization of the levels of relevant serum enzymes indicative for the pathophysiological status of the liver.

Applied Biotechnology Research Center Baqiyatallah University of Medical SciencesTehran Iran

Department of Pharmaceutical Botany Iuliu Haţieganu University of Medicine and PharmacyCluj Napoca Romania

Department of Pharmaceutical Sciences Faculty of Technology Kumaun UniversityNainital India

Department of Pharmacognosy University of ViennaVienna Austria

Department of Public Health Xi'an Jiaotong Liverpool UniversitySuzhou China

Department of Vascular Biology and Thrombosis Research Centre for Physiology and Pharmacology Medical University of ViennaVienna Austria

Division BIOCEV Institute of Molecular Genetics Academy of Sciences of the Czech RepublicPrague Czechia

ICHAT and Institute for Life Sciences University of Agricultural Sciences and Veterinary MedicineCluj Napoca Romania

Institute of Genetics and Animal Breeding of the Polish Academy of SciencesJastrzebiec Poland

School of Medical Sciences Universiti Sains MalaysiaKota Bharu Malaysia

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Front Pharmacol. 2017 Oct 06;8:690. doi: 10.3389/fphar.2017.00690. PubMed

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