Biomarkers in Immunoglobulin Light Chain Amyloidosis
Jazyk angličtina Země Česko Médium print
Typ dokumentu časopisecké články, multicentrická studie
PubMed
28903572
DOI
10.14735/amko20172s60
PII: 61621
Knihovny.cz E-zdroje
- MeSH
- biologické markery analýza MeSH
- lidé MeSH
- plazmatické buňky patologie MeSH
- primární amyloidóza krev genetika MeSH
- stanovení celkové genové exprese MeSH
- transkriptom MeSH
- volné cirkulující nukleové kyseliny MeSH
- vysoce účinné nukleotidové sekvenování MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
- Názvy látek
- biologické markery MeSH
- volné cirkulující nukleové kyseliny MeSH
Immunoglobulin light chain amyloidosis (AL amyloidosis - ALA) is a monoclonal gammopathy characterized by presence of aberrant plasma cells producing amyloidogenic immunoglobulin light chains. This leads to formation of amyloid fibrils in various organs and tissues, mainly in heart and kidney, and causes their dysfunction. As amyloid depositing in target organs is irreversible, there is a big effort to identify biomarker that could help to distinguish ALA from other monoclonal gammopathies in the early stages of disease, when amyloid deposits are not fatal yet. High throughput technologies bring new opportunities to modern cancer research as they enable to study disease within its complexity. Sophisticated methods such as next generation sequencing, gene expression profiling and circulating microRNA profiling are new approaches to study aberrant plasma cells from patients with light chain amyloidosis and related diseases. While generally known mutation in multiple myeloma patients (KRAS, NRAS, MYC, TP53) were not found in ALA, number of mutated genes is comparable. Transcriptome of ALA patients proves to be more similar to monoclonal gammopathy of undetermined significance patients, moreover level of circulating microRNA, that are known to correlate with heart damage, is increased in ALA patients, where heart damage in ALA typical symptom.Key words: amyloidosis - plasma cell - genome - transcriptome - microRNA.
Citace poskytuje Crossref.org