Multifunctional energy landscape for a DNA G-quadruplex: An evolved molecular switch
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články
PubMed
29055346
DOI
10.1063/1.4997377
Knihovny.cz E-zdroje
- MeSH
- DNA chemie genetika MeSH
- G-kvadruplexy * MeSH
- lidé MeSH
- molekulární modely MeSH
- simulace molekulární dynamiky MeSH
- telomery chemie genetika MeSH
- termodynamika MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- DNA MeSH
We explore the energy landscape for a four-fold telomere repeat, obtaining interconversion pathways between six experimentally characterised G-quadruplex topologies. The results reveal a multi-funnel system, with a variety of intermediate configurations and misfolded states. This organisation is identified with the intrinsically multi-functional nature of the system, suggesting a new paradigm for the classification of such biomolecules and clarifying issues regarding apparently conflicting experimental results.
Citace poskytuje Crossref.org
Structural dynamics of propeller loop: towards folding of RNA G-quadruplex
