Multifunctional energy landscape for a DNA G-quadruplex: An evolved molecular switch
Language English Country United States Media print
Document type Journal Article
PubMed
29055346
DOI
10.1063/1.4997377
Knihovny.cz E-resources
- MeSH
- DNA chemistry genetics MeSH
- G-Quadruplexes * MeSH
- Humans MeSH
- Models, Molecular MeSH
- Molecular Dynamics Simulation MeSH
- Telomere chemistry genetics MeSH
- Thermodynamics MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- DNA MeSH
We explore the energy landscape for a four-fold telomere repeat, obtaining interconversion pathways between six experimentally characterised G-quadruplex topologies. The results reveal a multi-funnel system, with a variety of intermediate configurations and misfolded states. This organisation is identified with the intrinsically multi-functional nature of the system, suggesting a new paradigm for the classification of such biomolecules and clarifying issues regarding apparently conflicting experimental results.
References provided by Crossref.org
Structural dynamics of propeller loop: towards folding of RNA G-quadruplex
