Flying Gaussian method simulates multiple replicas of the studied system and enhances sampling by disfavoring replicas to simultaneously sample similar states. The bias potential used for this enhancement is highly dynamic when looking at individual replica, which raises concerns about the accuracy of free-energy surfaces predicted by reweighing methods. Here we show that the bias potential can be considered as static when looking at the simulation from a multisystem perspective. We present two equations that can be used to predict the free-energy surface, and we demonstrate their convergence.

Department of Biochemistry and Microbiology University of Chemistry and Technology Prague Technická 5 166 28 Praha 6 Czech Republic

Department of Mathematics University of Chemistry and Technology Prague Technická 5 166 28 Praha 6 Czech Republic

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