Molecular Profiling of Mammary Analog Secretory Carcinoma Revealed a Subset of Tumors Harboring a Novel ETV6-RET Translocation: Report of 10 Cases
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Adult MeSH
- Phenotype MeSH
- Gene Fusion * MeSH
- Genetic Predisposition to Disease MeSH
- In Situ Hybridization, Fluorescence MeSH
- Immunohistochemistry MeSH
- Middle Aged MeSH
- Humans MeSH
- Biomarkers, Tumor analysis genetics MeSH
- Salivary Gland Neoplasms chemistry genetics pathology MeSH
- Predictive Value of Tests MeSH
- ETS Translocation Variant 6 Protein MeSH
- Proto-Oncogene Proteins c-ets genetics MeSH
- Proto-Oncogene Proteins c-ret genetics MeSH
- Registries MeSH
- Repressor Proteins genetics MeSH
- Mammary Analogue Secretory Carcinoma chemistry genetics pathology MeSH
- Aged MeSH
- Gene Expression Profiling methods MeSH
- Transcriptome MeSH
- Translocation, Genetic * MeSH
- High-Throughput Nucleotide Sequencing MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Biomarkers, Tumor MeSH
- Proto-Oncogene Proteins c-ets MeSH
- Proto-Oncogene Proteins c-ret MeSH
- Repressor Proteins MeSH
- RET protein, human MeSH Browser
ETV6 gene abnormalities are well described in tumor pathology. Many fusion partners of ETV6 have been reported in a variety of epithelial, mesenchymal, and hematological malignancies. In salivary gland tumor pathology, however, the ETV6-NTRK3 translocation is specific for (mammary analog) secretory carcinoma, and has not been documented in any other salivary tumor type. The present study comprised a clinical, histologic, and molecular analysis of 10 cases of secretory carcinoma, with typical morphology and immunoprofile harboring a novel ETV6-RET translocation.
Biomedical Center Faculty of Medicine in Pilsen Charles University
Bioptic Laboratory Ltd Molecular Pathology Laboratory
Clinical Oncology Oncological Clinic Faculty of Medicine in Plzen
Department of Anatomical Pathology University of Calgary and Foothills Medical Centre Calgary AB
Department of Pathology and Molecular Pathology University Hospital Zurich Zurich Switzerland
Department of Pathology University Health Network Toronto ON Canada
Department of Pathology University of Alabama at Birmingham Birmingham AL
Faculty of Education University of West Bohemia Plzen Czech Republic
Ignyta Inc San Diego California United States
References provided by Crossref.org
Molecular pathology in diagnosis and prognostication of head and neck tumors
