(Mammary Analogue) Secretory Carcinoma of the Nasal Cavity: Report of a Rare Case with p63 and DOG1 Expression and Uncommon Exon 4-Exon 14 ETV6-NTRK3 Fusion Diagnosed with Next Generation Sequencing
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu kazuistiky, časopisecké články
PubMed
31273600
PubMed Central
PMC7235099
DOI
10.1007/s12105-019-01051-z
PII: 10.1007/s12105-019-01051-z
Knihovny.cz E-zdroje
- Klíčová slova
- ETV6-NTRK3 fusion protein, human, Immunohistochemistry, Mammary analogue secretory carcinoma, Nasal cavity,
- MeSH
- anoctamin 1 biosyntéza MeSH
- exony genetika MeSH
- fúzní onkogenní proteiny genetika MeSH
- lidé MeSH
- membránové proteiny biosyntéza MeSH
- nádorové biomarkery analýza MeSH
- nádorové proteiny biosyntéza MeSH
- nádory nosu genetika patologie MeSH
- nosní dutina patologie MeSH
- sekreční karcinom mamárního typu genetika patologie MeSH
- sekvenční analýza DNA MeSH
- senioři MeSH
- vysoce účinné nukleotidové sekvenování MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
- Názvy látek
- ANO1 protein, human MeSH Prohlížeč
- anoctamin 1 MeSH
- CKAP4 protein, human MeSH Prohlížeč
- ETV6-NTRK3 fusion protein, human MeSH Prohlížeč
- fúzní onkogenní proteiny MeSH
- membránové proteiny MeSH
- nádorové biomarkery MeSH
- nádorové proteiny MeSH
We present a 72 years old male with a left nasal cavity (mammary analogue) secretory carcinoma (SC) which exhibited classical morphological features on light microscopical examination, diffuse strong S100 and mammoglobin positivity on immunohistochemistry, and ETV6-NTRK3 gene fusion on next generation sequencing (NGS) analysis. Unusual features of this tumor are expression of p63 and DOG1 on immunohistochemistry and the atypical junction between Exon 4 of the ETV6 gene and Exon 14 of the NTRK3 gene.
Department of Otolaryngology National University Health System Singapore Singapore
Department of Pathology Faculty of Medicine in Plzen Charles University Plzen Czech Republic
Molecular and Genetic Laboratory Biopticka Laboratory Ltd Plzen Czech Republic
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