Secretory Carcinoma of the Skin: Report of 6 Cases, Including a Case With a Novel NFIX-PKN1 Translocation
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Databases, Factual MeSH
- Phenotype MeSH
- Gene Fusion * MeSH
- Genetic Predisposition to Disease MeSH
- In Situ Hybridization, Fluorescence MeSH
- Immunohistochemistry MeSH
- Carcinoma chemistry genetics pathology surgery MeSH
- Middle Aged MeSH
- Humans MeSH
- Biomarkers, Tumor analysis genetics MeSH
- Skin Neoplasms chemistry genetics pathology surgery MeSH
- Reverse Transcriptase Polymerase Chain Reaction MeSH
- Prospective Studies MeSH
- Protein Kinase C genetics MeSH
- Retrospective Studies MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- NFI Transcription Factors genetics MeSH
- Translocation, Genetic * MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Biomarkers, Tumor MeSH
- NFIX protein, human MeSH Browser
- protein kinase N MeSH Browser
- Protein Kinase C MeSH
- NFI Transcription Factors MeSH
Secretory carcinoma of the skin is a rare adnexal carcinoma, which is morphologically and immunohistochemically identical to secretory carcinoma of the breast and is associated with the presence of t (12;15) translocation, resulting in the ETV6-NTRK3 gene fusion. Nineteen cases of primary cutaneous secretory carcinoma have been previously published in the literature. In this study, we describe 6 new cases of secretory carcinoma of the skin. The study group consisted of 5 female patients and 1 male patient, ranging in age from 57 to 98 years (mean: 74.2, median: 74). Locations included the axilla (2), neck, eyelid, thigh, and nipple base, each one. Microscopically, all but 1 tumor were well circumscribed and nonencapsulated and exhibited characteristic abundant secretions within the microcystic and tubular spaces comprised by bland oval, round to cuboidal neoplastic cells. In addition, solid areas and focal pseudopapillae were seen, and, in 1 case, a focal mucinous component with small lakes of mucin containing small tumor nests or tubules of the neoplastic cells was present. The remaining neoplasm was mostly solid and papillary, with only few characteristic lumina containing secretions. Immunohistochemically, all cases expressed S-100 protein, mammaglobin, STAT5, GATA3, and NTRK. ETV6-NTRK3 gene fusion was detected in 5 cases, whereas, in the remaining tumor, a novel NFIX-PKN1 gene fusion was found.
Bioptical Laboratory Pilsen Czech Republic
Department of Dermatology Hyogo Cancer Center Akashi
Department of Dermatology University Hospital Zurich Zurich Switzerland
Department of Diagnostic Pathology and Cytology Osaka International Cancer Institute Osaka
Department of Diagnostic Pathology Shizuoka Cancer Center Hospital Nagaizumi
Department of Pathology Caris Life Sciences Phoenix AZ
Department of Pathology Itabashi Central Clinical Laboratory Tokyo
Department of Pathology Moscow City Oncology Hospital №62 Moscow Russia
Department of Pathology Tokyo Metropolitan Cancer and Infectious Disease Center Komagome Hospital
Department of Surgical Pathology Hokkaido University Hospital Sapporo Japan
Institute of Pathology Medical Faculty University of Ljubljana Ljubljana Slovenia
Pathology Division Mie University Hospital Tsu
Sikl's Department of Pathology Medical Faculty in Pilsen Charles University Prague
References provided by Crossref.org