Poly(I:C) model of schizophrenia in rats induces sex-dependent functional brain changes detected by MRI that are not reversed by aripiprazole treatment
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
29155259
DOI
10.1016/j.brainresbull.2017.11.008
PII: S0361-9230(17)30582-8
Knihovny.cz E-zdroje
- Klíčová slova
- Aripiprazole *, Arterial Spin Labelling *, MRI *, Schizophrenia *, Sex *, Wistar rats *,
- MeSH
- antipsychotika farmakologie MeSH
- aripiprazol farmakologie MeSH
- magnetická rezonanční tomografie MeSH
- modely nemocí na zvířatech MeSH
- mozek diagnostické zobrazování účinky léků patofyziologie MeSH
- mozkový krevní oběh účinky léků fyziologie MeSH
- náhodné rozdělení MeSH
- pohlavní dimorfismus * MeSH
- poly I-C MeSH
- potkani Wistar MeSH
- schizofrenie diagnostické zobrazování farmakoterapie patofyziologie MeSH
- těhotenství MeSH
- zpožděný efekt prenatální expozice MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- antipsychotika MeSH
- aripiprazol MeSH
- poly I-C MeSH
BACKGROUND AND PURPOSE: One of the hallmarks of schizophrenia is altered brain structure, potentially due to antipsychotic treatment, the disorder itself or both. It was proposed that functional changes may precede the structural ones. In order to understand and potentially prevent this unwanted process, brain function assessment should be validated as a diagnostic tool. METHODS: We used Arterial Spin Labelling MRI technique for the evaluation of brain perfusion in several brain regions in a neurodevelopmental poly(I:C) model of schizophrenia (8mg/kg on a gestational day 15) in rats taking into account sex-dependent effects and chronic treatment with aripiprazole (30days), an atypical antipsychotic acting as a partial agonist on dopaminergic receptors. RESULTS: We found the sex of the animal to have a highly significant effect in all regions of interest, with females showing lower blood perfusion than males. However, both males and females treated prenatally with poly(I:C) showed enlargement of the lateral ventricles. Furthermore, we detected increased perfusion in the circle of Willis, hippocampus, and sensorimotor cortex, which was not influenced by chronic atypical antipsychotic aripiprazole treatment in male poly(I:C) rats. CONCLUSION: We hypothesize that perfusion alterations may be caused by the hyperdopaminergic activity in the poly(I:C) model, and the absence of aripiprazole effect on perfusion in brain regions related to schizophrenia may be due to its partial agonistic mechanism.
Department of Pharmacology Faculty of Medicine Masaryk University Brno Czech Republic
Department of Psychiatry University Hospital and Masaryk University Brno Czech Republic
Institute of Scientific Instruments The Czech Academy of Sciences Brno Czech Republic
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