Clinicopathological correlation of tumor-associated macrophages in Ewing sarcoma
Jazyk angličtina Země Česko Médium print-electronic
Typ dokumentu časopisecké články
PubMed
29170560
DOI
10.5507/bp.2017.049
Knihovny.cz E-zdroje
- Klíčová slova
- CD163, CD68, Ewing sarcoma, immunohistochemistry, prognosis, tumor associated macrophages,
- MeSH
- antigen CD163 MeSH
- antigeny diferenciační myelomonocytární fyziologie MeSH
- CD antigeny fyziologie MeSH
- dítě MeSH
- dospělí MeSH
- Ewingův sarkom patologie MeSH
- imunohistochemie MeSH
- lidé MeSH
- makrofágy metabolismus MeSH
- mladiství MeSH
- mladý dospělý MeSH
- nádorové buněčné linie metabolismus MeSH
- nádorové mikroprostředí MeSH
- pilotní projekty MeSH
- předškolní dítě MeSH
- proliferace buněk fyziologie MeSH
- receptory buněčného povrchu fyziologie MeSH
- Check Tag
- dítě MeSH
- dospělí MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- předškolní dítě MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- antigen CD163 MeSH
- antigeny diferenciační myelomonocytární MeSH
- CD antigeny MeSH
- CD68 antigen, human MeSH Prohlížeč
- receptory buněčného povrchu MeSH
AIMS: Tumor-associated macrophages (TAMs) are known markers playing complex roles in tumorigenesis. However, the function of TAMs in a variety of malignancies is not yet fully understood. The aim of this pilot study was to quantify the density of TAMs in Ewing sarcoma and to determine the correlation between TAMs and clinicopathological parameters. METHODS: Using immunohistochemistry, the expressions of CD68 and CD163 were examined in 24 tissue samples of Ewing sarcoma of bone. The density of CD68 and CD163-positive TAMs was analyzed quantitatively and semi-quantitatively and statistically correlated with clinical parameters. RESULTS: CD163-positive TAMs outnumbered CD68-positive cells (median of 130 vs 96, respectively). No statistically significant relatio nship was found between density of CD68-positive cells, clinical parameters or prognosis. However, high levels of CD163-positive TAMs were associated with localized disease (P=0.008). In cases with a higher density of CD163-positive cells, a trend toward longer survival was revealed (P=0.063). CONCLUSION: This is the first study that has quantified CD163 expression in TAMs in Ewing sarcoma and showed its possible prognostic value. CD163 was confirmed to be a more specific marker of macrophages than CD68. CD163 is not an exclusive hallmark of M2 macrophages.
Faculty of Medicine Masaryk University Brno Czech Republic
Institute of Biostatistics and Analyses Masaryk University Brno Czech Republic
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