A novel conditional Aire allele enables cell-specific ablation of the immune tolerance regulator Aire
Language English Country Germany Media print-electronic
Document type Letter, Research Support, Non-U.S. Gov't
PubMed
29193031
DOI
10.1002/eji.201747267
Knihovny.cz E-resources
- Keywords
- Aire, Conditional knockout, Immune tolerance, Medullary thymic epithelial cells,
- MeSH
- Antigen-Presenting Cells pathology MeSH
- Polyendocrinopathies, Autoimmune genetics immunology pathology MeSH
- Cell Lineage genetics immunology MeSH
- Immune Tolerance genetics MeSH
- Humans MeSH
- Mice, Knockout MeSH
- Mice, Transgenic MeSH
- Mice MeSH
- AIRE Protein MeSH
- Reproduction genetics immunology MeSH
- Transcription Factors genetics immunology MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Mice MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Letter MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Transcription Factors MeSH
Medullary thymic epithelial cell (mTEC)-restricted expression of autoimmune regulator (Aire) is essential for establishment of immune tolerance. Recently, Aire was also shown to be expressed in cells of hematopietic and reproductive lineages. Thus, the generation of Airefl/fl mouse strain enables the investigation of the cell-specific function of Aire.
Department of Cell biology Faculty of Science Charles University Prague Prague Czech Republic
References provided by Crossref.org
Extrathymic AIRE-Expressing Cells: A Historical Perspective
AIRE in Male Fertility: A New Hypothesis
