Intended and Unintended Targeting of Polymeric Nanocarriers: The Case of Modified Poly(glycerol adipate) Nanoparticles
Language English Country Germany Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- Keywords
- adrenals, biodegradable polymers, bones, nanoparticles, ovaries,
- MeSH
- Biodegradable Plastics chemistry MeSH
- HT29 Cells MeSH
- Fluorescent Dyes chemistry MeSH
- Drug Delivery Systems * MeSH
- Humans MeSH
- Methacrylates administration & dosage chemistry MeSH
- Mice MeSH
- Neoplasms drug therapy genetics pathology MeSH
- Nanoparticles administration & dosage chemistry MeSH
- Drug Carriers administration & dosage chemistry MeSH
- Polyesters administration & dosage chemistry MeSH
- Tissue Distribution drug effects MeSH
- Xenograft Model Antitumor Assays MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Biodegradable Plastics MeSH
- Fluorescent Dyes MeSH
- hydroxypropyl methacrylate MeSH Browser
- Methacrylates MeSH
- Drug Carriers MeSH
- poly(glycerol-adipate) MeSH Browser
- Polyesters MeSH
Biodegradable nanoparticles based on stearic acid-modified poly(glycerol adipate) (PGAS) are promising carriers for drug delivery. In order to investigate the impact of the particle interface characteristics on the biological fate, PGAS nanoparticles are covalently and noncovalently coated with N-(2-hydroxypropyl) methacrylamide (HPMA) copolymers. HPMA copolymer-modified PGAS nanoparticles have similar particle sizes, but less negative zeta-potentials. Nanoparticles are double labeled with the fluorescent dyes DiR (noncovalently) and DYOMICS-676 (covalently bound to HPMA copolymer), and their biodistribution is investigated noninvasively by multispectral optical imaging. Both covalent and noncovalent coatings cause changes in the pharmacokinetics and biodistribution in healthy and tumor-bearing mice. In addition to the intended tumor accumulation, high signals of both fluorescent dyes are also observed in other organs, including liver, ovaries, adrenal glands, and bone. The unintended accumulation of nanocarriers needs further detailed and systematic investigations, especially with respect to the observed ovarian and adrenal gland accumulation.
Department of Biomimetic Materials Institute of Biomaterial Science HZG Teltow 14513 Teltow Germany
Department of Internal Medicine 4 Germany
Institute of Chemistry Martin Luther University Halle Wittenberg 06120 Halle Germany
Institute of Macromolecular Chemistry Czech Academy of Science 162 06 Prague 6 Czech Republic
Institute of Pharmacy Martin Luther University Halle Wittenberg 06120 Halle Germany
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