Mannitol treatment is not effective in therapy of rabies virus infection in mice
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
29274698
DOI
10.1016/j.vaccine.2017.12.028
PII: S0264-410X(17)31781-4
Knihovny.cz E-resources
- Keywords
- Blood–brain barrier, Mannitol, Rabies, Therapy,
- MeSH
- Antigens, Viral metabolism MeSH
- Central Nervous System drug effects metabolism MeSH
- Blood-Brain Barrier drug effects metabolism MeSH
- Mannitol therapeutic use MeSH
- Mice, Inbred C57BL MeSH
- Mice MeSH
- Antibodies, Viral metabolism MeSH
- Rabies virus drug effects pathogenicity MeSH
- Rabies drug therapy virology MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Antigens, Viral MeSH
- Mannitol MeSH
- Antibodies, Viral MeSH
Rabies is a deadly viral disease with an extremely high fatality rate in humans. Previously, it was suggested that an enhancement of the blood-brain barrier (BBB) permeability, which allows immune cells and/or antibodies to enter the central nervous system (CNS) tissue, is critical to clear the infection. In this study, we utilised mannitol to increase BBB permeability in mice infected with highly pathogenic silver-haired bat rabies virus (SHBRV). We found that intraperitoneal injection of mannitol causes a slight, transient increase of BBB permeability in the treated mice. SHBRV-infected mice were treated with intraperitoneally administered mannitol daily from day 3 or day 4 post-infection, but no effect of this treatment on the time of disease onset, clinical signs or survival was observed. This data indicates that the increase of BBB permeability by mannitol is not efficient in promoting CNS virus clearance in SHBRV-infected mice.
Department of Virology Veterinary Research Institute Hudcova 70 CZ 62100 Brno Czech Republic
Viroscience Lab Erasmus Medical Center P O Box 2040 Ee1726 3000 CA Rotterdam The Netherlands
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