Contribution to Malaria Transmission of Symptomatic and Asymptomatic Parasite Carriers in Cambodia
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu klinické zkoušky, časopisecké články, randomizované kontrolované studie, práce podpořená grantem, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.
PubMed
29394367
DOI
10.1093/infdis/jiy060
PII: 4831066
Knihovny.cz E-zdroje
- MeSH
- Anopheles parazitologie MeSH
- dítě MeSH
- dospělí MeSH
- komáří přenašeči parazitologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- malárie vivax parazitologie přenos MeSH
- mladý dospělý MeSH
- paraziti patogenita MeSH
- Plasmodium falciparum patogenita MeSH
- Plasmodium vivax patogenita MeSH
- prevalence MeSH
- tropická malárie parazitologie přenos MeSH
- zvířata MeSH
- Check Tag
- dítě MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- klinické zkoušky MeSH
- práce podpořená grantem MeSH
- randomizované kontrolované studie MeSH
- Research Support, U.S. Gov't, Non-P.H.S. MeSH
- Research Support, U.S. Gov't, P.H.S. MeSH
- Geografické názvy
- Kambodža MeSH
BACKGROUND: Eliminating falciparum malaria in Cambodia is a top priority, requiring the implementation of novel tools and strategies to interrupt its transmission. To date, few data are available regarding the contributions to malaria transmission of symptomatic and asymptomatic carriers. METHODS: Direct-membrane and skin feeding assays (DMFAs, SFAs) were performed, using Anopheles minimus and Anopheles dirus, to determine infectivity of symptomatic falciparum-infected patients and malaria asymptomatic carriers; a subset of the latter were followed up for 2 months to assess their transmission potential. RESULTS: By microscopy and real-time polymerase chain reaction, Plasmodium falciparum gametocyte prevalence rates were, respectively, 19.3% (n = 21/109) and 44% (n = 47/109) on day (D) 0 and 17.9% (n = 5/28) and 89.3% (n = 25/28) in recrudescent patients (Drec) (RT-PCR Drec vs D0 P = .002). Falciparum malaria patient infectivity was low on D0 (6.2%; n = 3/48) and in Drec (8.3%; n = 1/12). Direct-membrane feeding assays and SFAs gave similar results. None of the falciparum (n = 0/19) and 3 of 28 Plasmodium vivax asymptomatic carriers were infectious to mosquitoes, including those that were followed up for 2 months. Overall, P. falciparum gametocytemias were low except in a few symptomatic carriers. CONCLUSIONS: Only symptomatic falciparum malaria patients were infectious to mosquito vectors at baseline and recrudescence, highlighting the need to detect promptly and treat effectively P. falciparum patients.
Mahidol Oxford Tropical Medicine Research Unit Mahidol University Bangkok Thailand
Malaria Molecular Epidemiology Unit Institut Pasteur in Cambodia Phnom Penh Cambodia
National Center for Parasitology Entomology and Malaria Control Program Phnom Penh Cambodia
School of Public Health National Institute of Public Health Phnom Penh Cambodia
Unité Biologie des Interactions Hôte Parasite Institut Pasteur Paris France
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