Obesity, dyslipidemia and brain age in first-episode psychosis
Jazyk angličtina Země Velká Británie, Anglie Médium print-electronic
Typ dokumentu časopisecké články
PubMed
29454222
DOI
10.1016/j.jpsychires.2018.02.012
PII: S0022-3956(17)31214-1
Knihovny.cz E-zdroje
- Klíčová slova
- BrainAGE score, Dyslipidemia, First-episode psychosis, Obesity, Overweight, Schizophrenia,
- MeSH
- dospělí MeSH
- dyslipidemie krev epidemiologie MeSH
- komorbidita MeSH
- lidé MeSH
- magnetická rezonanční tomografie MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mozek diagnostické zobrazování patologie MeSH
- nadváha diagnostické zobrazování epidemiologie metabolismus MeSH
- obezita diagnostické zobrazování epidemiologie metabolismus MeSH
- psychotické poruchy diagnostické zobrazování epidemiologie patologie MeSH
- rizikové faktory MeSH
- rozpoznávání automatizované MeSH
- schizofrenie diagnostické zobrazování epidemiologie patologie MeSH
- strojové učení MeSH
- věkové faktory MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
INTRODUCTION: Obesity and dyslipidemia may negatively affect brain health and are frequent medical comorbidities of schizophrenia and related disorders. Despite the high burden of metabolic disorders, little is known about their effects on brain structure in psychosis. We investigated, whether obesity or dyslipidemia contributed to brain alterations in first-episode psychosis (FEP). METHODS: 120 participants with FEP, who were undergoing their first psychiatric hospitalization, had <24 months of untreated psychosis and were 18-35 years old and 114 controls within the same age range participated in the study. We acquired 3T brain structural MRI, fasting lipids and body mass index. We used machine learning trained on an independent sample of 504 controls to estimate the individual brain age of study participants and calculated the BrainAGE score by subtracting the chronological from the estimated brain age. RESULTS: In a multiple regression model, the diagnosis of FEP (B = 1.15, SE B = 0.31, p < 0.001) and obesity/overweight (B = 0.92, SE B = 0.35, p = 0.008) were each additively associated with BrainAGE scores (R2 = 0.22, F(3, 230) = 21.92, p < 0.001). BrainAGE scores were highest in participants with FEP and obesity/overweight (3.83 years, 95%CI = 2.35-5.31) and lowest in normal weight controls (-0.27 years, 95%CI = -1.22-0.69). LDL-cholesterol, HDL-cholesterol or triglycerides were not associated with BrainAGE scores. CONCLUSIONS: Overweight/obesity may be an independent risk factor for diffuse brain alterations manifesting as advanced brain age already early in the course of psychosis. These findings raise the possibility that targeting metabolic health and intervening already at the level of overweight/obesity could slow brain ageing in FEP.
Dalhousie University Department of Psychiatry 5909 Veteran's Memorial Lane Halifax NS B3H 2E2 Canada
National Institute of Mental Health Topolová 748 250 67 Klecany Czech Republic
Citace poskytuje Crossref.org
Obesity and brain structure in schizophrenia - ENIGMA study in 3021 individuals
Higher Body-Mass Index and Lower Gray Matter Volumes in First Episode of Psychosis
