Microbial colonization of biomedical devices is a recognized complication contributing to healthcare-associated infections. One of the possible approaches to prevent surfaces from the biofilm formation is antimicrobial photodynamic inactivation based on the cytotoxic effect of singlet oxygen, O2(1Δg), a short-lived, highly oxidative species, produced by energy transfer between excited photosensitizers and molecular oxygen. We synthesized porphyrin-based covalent organic frameworks (COFs) by Schiff-base chemistry. These novel COFs have a three-dimensional, diamond-like structure. The detailed analysis of their photophysical and photochemical properties shows that the COFs effectively produce O2(1Δg) under visible light irradiation, and especially three-dimensional structures have strong antibacterial effects toward Pseudomonas aeruginosa and Enterococcus faecalis biofilms. The COFs exhibit high photostability and broad spectral efficiency. Hence, the porphyrinic COFs are suitable candidates for the design of antibacterial coating for indoor applications.

Department of Biochemistry and Microbiology University of Chemistry and Technology Prague Technická 5 166 28 Praha 6 Czech Republic

Department of Inorganic Chemistry Faculty of Science Charles University Hlavova 2030 128 43 Praha 2 Czech Republic

Institute of Inorganic Chemistry Czech Academy of Sciences Husinec Řež 1001 250 68 Řež Czech Republic

J Heyrovský Institute of Physical Chemistry Czech Academy of Sciences Dolejškova 3 182 23 Praha 8 Czech Republic

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