Small mammals as sentinels of antimicrobial-resistant staphylococci
Language English Country United States Media print-electronic
Document type Journal Article
Grant support
APVV-14-0274
Slovak Research and Development Agency
PubMed
29524153
DOI
10.1007/s12223-018-0594-3
PII: 10.1007/s12223-018-0594-3
Knihovny.cz E-resources
- MeSH
- Anti-Bacterial Agents pharmacology MeSH
- Drug Resistance, Bacterial genetics MeSH
- Animals, Wild MeSH
- Rodentia microbiology MeSH
- Coagulase analysis MeSH
- Methicillin-Resistant Staphylococcus aureus genetics MeSH
- Microbial Sensitivity Tests MeSH
- Microbial Viability drug effects MeSH
- Staphylococcal Infections microbiology MeSH
- Staphylococcus classification drug effects genetics isolation & purification MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Anti-Bacterial Agents MeSH
- Coagulase MeSH
A total of 39 coagulase-negative staphylococci and seven Staphylococcus aureus strains were isolated from small mammal feces, i.e., the striped field mouse (Apodemus agrarius) and the yellow-necked mouse (A. flavicollis) in two sampling areas, deciduous forest and karst plains. MALDI-TOF analysis revealed five species of coagulase-negative staphylococci: S. sciuri, S. hominis, S. warneri, S. haemolyticus, and S. xylosus. All strains were susceptible to tetracycline, linezolid, vancomycin, and teicoplanin. Three MRSA strains with the mecA gene were detected. The beta-lactamase gene blaZ was detected in ampicillin-resistant staphylococci and in the high-level resistant strains (oxacillin over 2 mg/L) mecA gene. The mecC gene was not detected by PCR. Erythromycin-resistant staphylococci harbored the ermC gene and/or the efflux gene msrA. There were no detectable dfr genes in trimethoprim-resistant staphylococci and the rifampicin-resistant strains were without mutation in the rpoB gene. In summary, wild small mammals may serve as sentinels of mecA-positive S. aureus with erythromycin resistance genes ermC and efflux msrA. Small mammals appear to be useful indicators of antibiotic resistance.
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