Mammary Analog Secretory Carcinoma of the Nasal Cavity: Characterization of 2 Cases and Their Distinction From Other Low-grade Sinonasal Adenocarcinomas
Language English Country United States Media print
Document type Case Reports, Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Adenocarcinoma chemistry genetics pathology MeSH
- Biopsy MeSH
- Diagnosis, Differential MeSH
- Oncogene Proteins, Fusion genetics MeSH
- In Situ Hybridization, Fluorescence MeSH
- Immunohistochemistry MeSH
- Middle Aged MeSH
- Humans MeSH
- Biomarkers, Tumor analysis genetics MeSH
- Nose Neoplasms chemistry genetics pathology surgery MeSH
- Nasal Cavity chemistry pathology surgery MeSH
- Tomography, X-Ray Computed MeSH
- Reverse Transcriptase Polymerase Chain Reaction MeSH
- Predictive Value of Tests MeSH
- Registries MeSH
- Mammary Analogue Secretory Carcinoma chemistry genetics pathology surgery MeSH
- Aged MeSH
- Neoplasm Grading MeSH
- High-Throughput Nucleotide Sequencing MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Case Reports MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- ETV6-NTRK3 fusion protein, human MeSH Browser
- Oncogene Proteins, Fusion MeSH
- Biomarkers, Tumor MeSH
Secretory carcinoma, originally described as mammary analog secretory carcinoma (MASC), is a low-grade salivary gland tumor characterized by a t(12;15)(p13;q25) translocation, resulting in an ETV6-NTRK3 gene fusion. Most MASCs are localized to the parotid gland and intraoral minor salivary glands. Moreover, ETV6-rearranged carcinomas with secretory features have been reported recently in the thyroid (with and without a history of radiation exposure), skin, and in very rare instances in the sinonasal tract. Here, we describe 2 cases of primary MASC in the sinonasal tract and provide a detailed clinical and histopathologic characterization of their morphology, immunohistochemical profile, and genetic background and highlight features allowing for its separation from its recently described molecular mimicker, ETV6-rearranged low-grade sinonasal adenocarcinoma.
Department of Molecular Pathology Bioptic Laboratory Ltd Plzen Czech Republic
Department of Otolaryngology Head and Neck Surgery Rigshospitalet Denmark
Department of Otorhinolaryngology and Maxillofacial Surgery Køge University Hospital
Institute of Pathology Friedrich Alexander University Erlangen Germany
Oncology and Radiotherapy Oncological Clinic Faculty of Medicine in Plzen Charles University
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