Medical cannabis in the treatment of cancer pain and spastic conditions and options of drug delivery in clinical practice
Language English Country Czech Republic Media print-electronic
Document type Journal Article, Review
PubMed
29560966
DOI
10.5507/bp.2018.007
Knihovny.cz E-resources
- Keywords
- THC, cancer, cannabinoids, cannabis, mechanism of action, multiple sclerosis, pain, spasms,
- MeSH
- Phytotherapy MeSH
- Cannabinoids administration & dosage pharmacology MeSH
- Humans MeSH
- Medical Marijuana administration & dosage pharmacology MeSH
- Cancer Pain drug therapy MeSH
- Analgesics, Opioid administration & dosage pharmacology MeSH
- Plant Preparations MeSH
- Muscle Spasticity drug therapy MeSH
- Drug Administration Routes MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
- Names of Substances
- Cannabinoids MeSH
- Medical Marijuana MeSH
- Analgesics, Opioid MeSH
- Plant Preparations MeSH
The use of cannabis for medical purposes has been recently legalised in many countries including the Czech Republic. As a result, there is increased interest on the part of physicians and patients in many aspects of its application. This mini review briefly covers the main active substances of the cannabis plant and mechanisms of action. It focuses on two conditions, cancer pain and spasticity in multiple sclerosis, where its effects are well-documented. A comprehensive overview of a few cannabis-based products and the basic pharmacokinetics of marijuana's constituents follows. The review concludes with an outline for preparing cannabis (dried inflorescence) containing drug dosage forms that can be produced in a hospital pharmacy.
Department of Pharmacology 3rd Faculty of Medicine Charles University Prague Prague Czech Republic
Department of Pharmacology Faculty of Medicine Masaryk University Brno Czech Republic
Hospital Pharmacy St Anne's University Hospital Brno Czech Republic
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