Alarmins as biomarkers of gastrointestinal surgical injury - a pilot study
Language English Country Denmark Media print
Document type Journal Article
PubMed
29700911
DOI
10.1111/apm.12798
Knihovny.cz E-resources
- Keywords
- Alarmins, biomarkers, gastrointestinal, major abdominal surgery,
- MeSH
- Alarmins blood MeSH
- Biomarkers blood MeSH
- C-Reactive Protein analysis MeSH
- Digestive System Surgical Procedures * MeSH
- Adult MeSH
- Calgranulin A blood MeSH
- Middle Aged MeSH
- Humans MeSH
- Pilot Projects MeSH
- Prospective Studies MeSH
- HMGB1 Protein blood MeSH
- Aged MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Alarmins MeSH
- Biomarkers MeSH
- C-Reactive Protein MeSH
- Calgranulin A MeSH
- HMGB1 Protein MeSH
The dysregulation of inflammatory response to surgical injury affects outcomes. Alarmins, the earliest bioactive substances from damaged cells, play a crucial role in initiating the inflammation. We analyzed serum levels of alarmins (S100A8, S100A12, high mobility group box, and heat shock protein 70) after major abdominal surgery (MAS) in surgical (S) (n = 82) and nonsurgical (NS) groups (n = 35). The main objective was determining a role of selected alarmins in host response to MAS. The secondary objectives were (i) evaluation of the relationship among alarmins and selected biomarkers (C-reactive protein, interleukin-6), (ii) influence of the place of gastrointestinal resection, and (iii) role of alarmins in MAS for cancer. Except for HMGB1, the levels of all alarmins were higher in the S group compared with the NS group. In the S group, positive correlations were found between S100A8 and both IL-6 and CRP. Additionally, the S100A8 level was higher (p < 0.01) in patients who underwent upper gastrointestinal tract (GIT) surgery compared to middle and lower GIT resections. Alarmins levels did not differ between cancer and noncancer patients. MAS is able to elicit increase in alarmin levels. S100A8 can be considered a potential biomarker of surgical injury, especially in the upper part of the GIT.
Department of Surgery University Hospital Ostrava Ostrava Poruba Czech Republic
Institute of Laboratory Diagnostics University Hospital Ostrava Ostrava Poruba Czech Republic
References provided by Crossref.org
Surgical injury: comparing open surgery and laparoscopy by markers of tissue damage
