Nature-derived microbiota exposure as a novel immunomodulatory approach
Language English Country Great Britain, England Media print-electronic
Document type Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't
PubMed
29771153
DOI
10.2217/fmb-2017-0286
Knihovny.cz E-resources
- Keywords
- 16s rRNA, biodiversity hypothesis, immune modulation, immune-mediated diseases, microbial diversity, microbiome,
- MeSH
- Bacteria classification genetics isolation & purification MeSH
- Biodiversity MeSH
- Adult MeSH
- Feces microbiology MeSH
- Gastrointestinal Tract immunology microbiology MeSH
- Immunity * MeSH
- Immunomodulation MeSH
- Skin immunology microbiology MeSH
- Middle Aged MeSH
- Humans MeSH
- Pilot Projects MeSH
- Soil chemistry MeSH
- Soil Microbiology * MeSH
- Plants microbiology MeSH
- Gastrointestinal Microbiome * MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Clinical Trial MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Soil MeSH
AIM: Current attempts to modulate the human microbiota and immune responses are based on probiotics or human-derived bacterial transplants. We investigated microbial modulation by soil and plant-based material. MATERIALS & METHODS: We performed a pilot study in which healthy adults were exposed to the varied microbial community of a soil- and plant-based material. RESULTS: The method was safe and feasible; exposure was associated with an increase in gut microbial diversity. CONCLUSION: If these findings are reproduced in larger studies nature-derived microbial exposure strategies could be further developed for testing their efficacy in the treatment and prevention of immune-mediated diseases.
Department of Internal Medicine Tampere University Hospital Teiskontie 35 33520 Tampere Finland
Fimlab Laboratories Pirkanmaa Hospital District Arvo Ylpön katu 4 33520 Tampere Finland
References provided by Crossref.org
Skin exposure to soil microbiota elicits changes in cell-mediated immunity to pneumococcal vaccine
