Hypomagnesaemia is absent in children with autosomal dominant polycystic kidney disease
Jazyk angličtina Země Velká Británie, Anglie Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
29874928
DOI
10.1177/0004563218785190
Knihovny.cz E-zdroje
- Klíčová slova
- Magnesium, autosomal dominant polycystic kidney disease, autosomal recessive polycystic kidney disease, children, hypomagnesaemia, renal cysts and diabetes syndrome,
- MeSH
- cystická onemocnění ledvin krev diagnóza epidemiologie MeSH
- diabetes mellitus 2. typu krev diagnóza epidemiologie MeSH
- diferenciální diagnóza MeSH
- dítě MeSH
- hořčík krev MeSH
- hyperkalciurie krev diagnóza epidemiologie MeSH
- kojenec MeSH
- lidé MeSH
- mladiství MeSH
- nefrokalcinóza krev diagnóza epidemiologie MeSH
- nemoci centrálního nervového systému krev diagnóza epidemiologie MeSH
- novorozenec MeSH
- polycystické ledviny autozomálně dominantní krev diagnóza epidemiologie MeSH
- polycystické ledviny autozomálně recesivní krev diagnóza epidemiologie MeSH
- předškolní dítě MeSH
- prevalence MeSH
- průřezové studie MeSH
- vrozené poruchy tubulárního transportu krev diagnóza epidemiologie MeSH
- zubní sklovina abnormality MeSH
- Check Tag
- dítě MeSH
- kojenec MeSH
- lidé MeSH
- mladiství MeSH
- mužské pohlaví MeSH
- novorozenec MeSH
- předškolní dítě MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- hořčík MeSH
BACKGROUND: Hypomagnesaemia is present in 40-50% of children with autosomal dominant renal cysts and diabetes syndrome (RCAD). On the contrary, the prevalence of hypomagnesaemia in children with autosomal dominant polycystic kidney disease (ADPKD) has never been examined. We aimed to investigate whether hypomagnesaemia is present in children with polycystic kidney diseases. METHODS: Children with cystic kidney diseases were investigated in a cross-sectional study. Serum concentrations of magnesium (S-Mg) and fractional excretion of magnesium (FE-Mg) were tested. Fifty-four children with ADPKD ( n = 26), autosomal recessive polycystic kidney disease (ARPKD) ( n = 16) and RCAD ( n = 12) with median age of 11.2 (0.6-18.6) years were investigated. RESULTS: Hypomagnesaemia (S-Mg < 0.7 mmol/L) was detected in none of the children with ADPKD/ARPKD and in eight children (67%) with RCAD. Median S-Mg in children with ADPKD/ARPKD was significantly higher than in children with RCAD (0.89 vs. 0.65 mmol/L, P < 0.01). The FE-Mg was increased in 23% of patients with ADPKD/ARPKD (all had chronic kidney disease stages 2-4) and in 63% of patients with RCAD, where it significantly correlated with estimated glomerular filtration rate (r = -0.87, P < 0.01). CONCLUSIONS: Hypomagnesaemia is absent in children with ADPKD or ARPKD and could serve as a marker for differential diagnostics between ADPKD, ARPKD and RCAD in children with cystic kidney diseases of unknown origin where molecular genetic testing is lacking. However, while hypomagnesaemia, in the absence of diuretics, appears to rule out ADPKD and ARPKD, normomagnesaemia does not rule out RCAD at least in those aged <3 years.
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